{"id":4224,"date":"2023-03-13T16:25:11","date_gmt":"2023-03-13T08:25:11","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?page_id=4224"},"modified":"2026-05-20T10:48:36","modified_gmt":"2026-05-20T02:48:36","slug":"phm5009","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/","title":{"rendered":"PHM5009 &#8211; Precision Oncology"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4224\" class=\"elementor elementor-4224\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1a7af21 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1a7af21\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1f1c220\" data-id=\"1f1c220\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-946348f elementor-widget elementor-widget-spacer\" data-id=\"946348f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d4c434 elementor-widget elementor-widget-heading\" data-id=\"6d4c434\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Course Overview<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43faf36 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43faf36\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-85384c6\" data-id=\"85384c6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f96a0ef elementor-widget elementor-widget-text-editor\" data-id=\"f96a0ef\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size: 14pt; color: #000000;\">This Master&#8217;s course in Precision Oncology will provide an in-depth exploration of the molecular and genomic foundations of cancer, emphasizing how these insights inform individualized diagnosis, prognosis, and treatment strategies. <\/span><\/p><p><span style=\"font-size: 14pt; color: #000000;\">Key topics include cancer hallmarks and genomics, identification of novel targetable vulnerabilities, biomarker <\/span><span style=\"font-size: 14pt; color: #000000;\">discovery and validation. The course also introduces core artificial intelligence and machine learning concepts, progressing from foundational mathematical principles to advanced deep learning and transformer-based models, with a focus on biomedical and medical imaging applications relevant to precision oncology. It also addresses model optimization and generalization, evaluation and validation, and the ethical considerations necessary for responsible AI deployment in healthcare. <\/span><\/p><p><span style=\"font-size: 14pt; color: #000000;\">We will also explore clinical applications of AI in <\/span><span style=\"font-size: 14pt; color: #000000;\">pathological diagnosis and surgical oncology as well as precision oncology applications in biotech, pharma and patient care.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8bc5c98 elementor-widget elementor-widget-spacer\" data-id=\"8bc5c98\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89981aa elementor-widget elementor-widget-heading\" data-id=\"89981aa\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Learning Outcomes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ded01ca elementor-widget elementor-widget-text-editor\" data-id=\"ded01ca\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div style=\"font-weight: 400;\"><ul style=\"list-style-type: disc;\"><li><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\" style=\"color: #000000; font-size: 14pt;\">Explain what precision oncology is and how it differs from traditional cancer care.\u00a0<\/span><\/li><li><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\" style=\"color: #000000; font-size: 14pt;\">Describe\u00a0the molecular and genomic basis of cancer: Key genetic, epigenetic, and\u00a0signaling\u00a0alterations involved in\u00a0tumor\u00a0initiation, progression, and metastasis.<\/span><\/li><li><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\" style=\"color: #000000; font-size: 14pt;\">Understand how genomic and other \u201comics\u201d data are generated and interpreted\u00a0and how these\u00a0data\u00a0can\u00a0inform\u00a0diagnosis, prognosis, and treatment.<\/span><\/li><li><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\" style=\"color: #000000; font-size: 14pt;\">Evaluate the role of advanced molecular diagnostics in the identification of therapeutic vulnerabilities in cancer.<\/span><\/li><li><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\" style=\"color: #000000; font-size: 14pt;\">Evaluate surgical strategies in relation to molecular profiles,\u00a0critically appraise the use of genomics in surgical decision-making, including risk-reduction surgeries.<\/span><\/li><li><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\" style=\"color: #000000; font-size: 14pt;\">Understand the principles of digital pathology and\u00a0use of\u00a0AI tools in modern oncologic pathology workflows.<\/span><\/li><li><span data-contrast=\"none\" xml:lang=\"EN-SG\" lang=\"EN-SG\" style=\"color: #000000; font-size: 14pt;\">Explain fundamental AI and machine learning principles, including regression, loss functions, and optimization.<\/span><\/li><li><span style=\"color: #000000; font-size: 14pt;\"><span data-contrast=\"none\" xml:lang=\"EN-SG\" lang=\"EN-SG\">Design, optimize, and evaluate machine learning models. <\/span><span data-contrast=\"none\" xml:lang=\"EN-SG\" lang=\"EN-SG\">Understand and apply deep learning architectures such as CNNs and RNNs for image and biomedical data.<\/span><\/span><\/li><li><span style=\"color: #000000; font-size: 14pt;\">A<span data-contrast=\"none\" xml:lang=\"EN-SG\" lang=\"EN-SG\">nalyze\u00a0and compare classical ML methods with modern deep learning approaches.<\/span><\/span><\/li><li><span style=\"color: #000000; font-size: 14pt;\"><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\">Develop\u00a0proficiency\u00a0in the use\u00a0of publicly available and\u00a0<\/span><span data-contrast=\"none\" xml:lang=\"EN-SG\" lang=\"EN-SG\">custom-designed bioinformatics tools<\/span><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\">\u00a0for precision oncology applications.<\/span><\/span><\/li><li><span style=\"color: #000000; font-size: 14pt;\"><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\">Recognize the\u00a0<\/span><span data-contrast=\"none\" xml:lang=\"EN-SG\" lang=\"EN-SG\">ethical, safety, and regulatory challenges<\/span><span data-contrast=\"none\" xml:lang=\"EN-SG\" lang=\"EN-SG\">\u00a0<\/span><span data-contrast=\"auto\" xml:lang=\"EN-SG\" lang=\"EN-SG\">involved in\u00a0precision oncology.<\/span><\/span><\/li><\/ul><\/div><div style=\"font-weight: 400;\"><ul role=\"list\"><\/ul><\/div><div style=\"font-weight: 400;\"><ul role=\"list\"><\/ul><\/div><div style=\"font-weight: 400;\"><ul role=\"list\"><\/ul><\/div><div style=\"font-weight: 400;\"><ul role=\"list\"><\/ul><\/div><div style=\"font-weight: 400;\"><ul role=\"list\"><\/ul><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c49a3c elementor-widget elementor-widget-spacer\" data-id=\"4c49a3c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b49c198 elementor-widget elementor-widget-heading\" data-id=\"b49c198\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Course Coordinators<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2794ccc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2794ccc\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-beec95b\" data-id=\"beec95b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-06d0084 elementor-cta--layout-image-left elementor-cta--skin-classic elementor-animated-content elementor-widget elementor-widget-call-to-action\" data-id=\"06d0084\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<a class=\"elementor-cta\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/tay-mei-sian-yvonne\/\" target=\"_blank\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2020\/01\/bchtmsy.jpg);\" role=\"img\" aria-label=\"bchtmsy\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tA\/Prof Yvonne Tay\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tAssociate Professor &amp; Principal Investigator, CSI, NUS\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<span class=\"elementor-cta__button elementor-button elementor-size-\">\n\t\t\t\t\t\tProfile\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b7d65af\" data-id=\"b7d65af\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7dad186 elementor-cta--layout-image-left elementor-cta--skin-classic elementor-animated-content elementor-widget elementor-widget-call-to-action\" data-id=\"7dad186\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<a class=\"elementor-cta\" href=\"https:\/\/www.a-star.edu.sg\/docs\/librariesprovider19\/science\/scientific-programme\/innovative-technologies\/weimiao-yu\/team.pdf\" target=\"_blank\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/01\/weimiao.png);\" role=\"img\" aria-label=\"weimiao\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDr Yu Weimiao\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tHead,\nComputational &amp; Molecular Pathology Lab (CMPL), Bioinformatics Institute, A*STAR\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<span class=\"elementor-cta__button elementor-button elementor-size-\">\n\t\t\t\t\t\tProfile\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Course Overview This course will\u00a0provide an in-depth exploration of the molecular and genomic foundations of cancer, emphasizing how these insights&#8230;<\/p>\n","protected":false},"author":8259,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4224","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PHM5009 - Precision Oncology - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PHM5009 - Precision Oncology - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Course Overview This course will\u00a0provide an in-depth exploration of the molecular and genomic foundations of cancer, emphasizing how these insights...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-20T02:48:36+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/\",\"name\":\"PHM5009 - Precision Oncology - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/#website\"},\"datePublished\":\"2023-03-13T08:25:11+00:00\",\"dateModified\":\"2026-05-20T02:48:36+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/phm5009\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/medicine.nus.edu.sg\/bch\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PHM5009 &#8211; 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