{"id":4141,"date":"2023-03-09T14:45:39","date_gmt":"2023-03-09T06:45:39","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?page_id=4141"},"modified":"2026-01-30T14:10:08","modified_gmt":"2026-01-30T06:10:08","slug":"phm5002","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/bch\/phm5002\/","title":{"rendered":"PHM5002 &#8211; Precision Proteomics and Metabolomics"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4141\" class=\"elementor elementor-4141\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1a7af21 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1a7af21\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1f1c220\" data-id=\"1f1c220\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-946348f elementor-widget elementor-widget-spacer\" data-id=\"946348f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d4c434 elementor-widget elementor-widget-heading\" data-id=\"6d4c434\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Course Overview<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43faf36 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43faf36\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-85384c6\" data-id=\"85384c6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f96a0ef elementor-widget elementor-widget-text-editor\" data-id=\"f96a0ef\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span lang=\"EN-GB\" style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">This module covers analytical methods and technologies that enable detection and quantification of key molecular descriptors of human health and disease, including proteins, metabolites, and lipids. The first half of the course introduces experimental workflows, instrumentation, and data quality control procedures across different application areas. The second half consists of a series of application-oriented lectures by experts who routinely deploy proteomic and metabolomic profiling methods in their own research areas. We will summarize current practices and future outlook in the context of emerging applications in precision medicine.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8bc5c98 elementor-widget elementor-widget-spacer\" data-id=\"8bc5c98\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89981aa elementor-widget elementor-widget-heading\" data-id=\"89981aa\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Learning Outcomes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ded01ca elementor-widget elementor-widget-text-editor\" data-id=\"ded01ca\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul style=\"list-style-type: disc;\"><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Understanding of pros and cons of the core technologies enabling proteomics and metabolomics analysis (LC-MS, affinity-based proteomics).<\/span><\/p><\/li><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Approaches to link genomic information to protein and small molecule data as surrogate outcomes.<\/span><\/p><\/li><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Evaluating the potential of emerging multi-omics approaches in the context of precision medicine.<\/span><\/p><\/li><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Understanding the challenges in the standardization of omics-level data and issues in scalability and reproducibility<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c49a3c elementor-widget elementor-widget-spacer\" data-id=\"4c49a3c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1797eb7 elementor-widget elementor-widget-heading\" data-id=\"1797eb7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Course Outline<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a0e2f5 elementor-widget elementor-widget-text-editor\" data-id=\"9a0e2f5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul style=\"list-style-type: disc;\"><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Principles of mass spectrometry, experimental workflows, and its application to proteomics<\/span><\/p><\/li><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Quantitative mass spectrometry in metabolomics and lipidomics<\/span><\/p><\/li><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Data processing and quality control<\/span><\/p><\/li><li><p><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">Application of proteomics, metabolomics, and lipidomics in clinical and biological research \u00a0<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdf22c5 elementor-widget elementor-widget-spacer\" data-id=\"bdf22c5\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b49c198 elementor-widget elementor-widget-heading\" data-id=\"b49c198\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Course Coordinators<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2794ccc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2794ccc\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-beec95b\" data-id=\"beec95b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-06d0084 elementor-cta--layout-image-left elementor-cta--skin-classic elementor-animated-content elementor-widget elementor-widget-call-to-action\" data-id=\"06d0084\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<a class=\"elementor-cta\" href=\"https:\/\/medicine.nus.edu.sg\/cvri\/associate-professor-choi-hyungwon\/\" target=\"_blank\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2023\/08\/CHW.jpg);\" role=\"img\" aria-label=\"CHW\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tA\/Prof Choi Hyung Won\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tAssociate Professor, Cardiovascular Research Institute (CVRI), NUHS\n<br><br>Associate Professor, Department of Medicine, YLLSOM, NUS\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<span class=\"elementor-cta__button elementor-button elementor-size-\">\n\t\t\t\t\t\tProfile\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b7d65af\" data-id=\"b7d65af\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7dad186 elementor-cta--layout-image-left elementor-cta--skin-classic elementor-animated-content elementor-widget elementor-widget-call-to-action\" data-id=\"7dad186\" data-element_type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<a class=\"elementor-cta\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/dennis-kappei\/\" target=\"_blank\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2023\/05\/Dennis-Kappei-1-e1594130846963.png);\" role=\"img\" aria-label=\"Dennis-Kappei-1-e1594130846963\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h2 class=\"elementor-cta__title elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDr Dennis Kappei\t\t\t\t\t<\/h2>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tAssistant Professor, Dept of Biochemistry, NUS\n<br><br>Principal Investigator, Cancer Science Institute, NUS\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<span class=\"elementor-cta__button elementor-button elementor-size-\">\n\t\t\t\t\t\tProfile\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Course Overview This module covers analytical methods and technologies that enable detection and quantification of key molecular descriptors of human&#8230;<\/p>\n","protected":false},"author":8259,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4141","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PHM5002 - Precision Proteomics and Metabolomics - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/phm5002\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PHM5002 - Precision Proteomics and Metabolomics - Department of Biochemistry \u2013 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