{"id":6154,"date":"2024-09-30T20:24:51","date_gmt":"2024-09-30T12:24:51","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&p=6154"},"modified":"2024-09-30T20:45:20","modified_gmt":"2024-09-30T12:45:20","slug":"xavier-chee-wezen","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/xavier-chee-wezen\/","title":{"rendered":"Xavier Chee Wezen"},"content":{"rendered":"

Affiliation<\/h3>\n

Lecturer, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS<\/p>\n

 <\/p>\n

Education<\/h3>\n\n\n\n\n\n
Institution and Location<\/strong><\/td>\nYear(s)<\/strong><\/td>\n<\/tr>\n
Ph.D. Pharmacology, University of Cambridge, UK<\/td>\n2017<\/td>\n<\/tr>\n
B.Sc. Chemistry (Hons), Imperial College London, UK<\/td>\n2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Professional Experience<\/h3>\n\n\n\n\n\n
Institution and Location<\/strong><\/td>\nYear(s)<\/strong><\/td>\n<\/tr>\n
Lecturer, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS, Singapore<\/td>\n2024 – Present<\/td>\n<\/tr>\n
Lecturer, School of Chemical Engineering and Science, Swinburne University of Technology Sarawak, Malaysia<\/td>\n2019 – 2024<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Research Interests<\/h3>\n

My research harnesses the power of computational techniques to revolutionize drug discovery. By integrating high-performance computing and machine learning with conventional computer-aided methods, my lab aims to streamline the drug discovery pipeline, potentially reducing the time and cost associated with bringing new therapeutics to market. A key area of our work involves developing cutting-edge ultra-large virtual screening platforms. These innovative tools efficiently explore vast chemical spaces, dramatically accelerating the process of uncovering novel inhibitors for a range of diseases. We primarily focus on antimicrobials, cancer therapeutics, and compounds that could impact the aging process. Additionally, I’m also interested in computational techniques to design small molecules targeting RNA, an emerging and exciting field in pharmaceutical research. This work not only pushes the boundaries of computational chemistry but also holds the promise of developing more effective treatments for some of society’s most pressing health challenges. Through these advanced computational approaches, my lab hopes to advance the field of computational drug discovery and pave the way for faster, more efficient development of life-changing medicines.<\/p>\n

Major research interests:<\/strong><\/p>\n

    \n
  1. Computer-aided drug design<\/li>\n
  2. Small molecule therapeutics development<\/li>\n
  3. RNA-based therapeutics<\/li>\n<\/ol>\n

     <\/p>\n

    Selected Publications<\/h3>\n
      \n
    1. Gunasinghe, K. K. J., Ginjom, I. R. H., San, H. S., Rahman, T. & Wezen, X. C. Can Current Molecular Docking Methods Accurately Predict RNA Inhibitors? J. Chem. Inf. Model. 64, 5954\u20135963 (2024).<\/li>\n
    2. Gunasinghe, K. K. J., Rahman, T. & Chee Wezen, X. Unraveling the Behavior of Intrinsically Disordered Protein c-Myc: A Study Utilizing Gaussian-Accelerated Molecular Dynamics. ACS Omega 9, 2250\u20132262 (2024).<\/li>\n
    3. Cheng, Z., Bhave, M., Hwang, S. S., Rahman, T. & Chee, X. W. Identification of Potential p38\u03b3 Inhibitors via In Silico Screening, In Vitro Bioassay and Molecular Dynamics Simulation Studies. Int. J. Mol. Sci. 24, 7360 (2023).<\/li>\n
    4. Koh, C. M. M. et al. A data-driven machine learning approach for discovering potent LasR inhibitors. Bioengineered 14, 2243416 (2023).<\/li>\n
    5. Cheng, Z., Hwang, S. S., Bhave, M., Rahman, T. & Chee Wezen, X. Combination of QSAR Modeling and Hybrid-Based Consensus Scoring to Identify Dual-Targeting Inhibitors of PLK1 and p38\u03b3. J. Chem. Inf. Model. 63, 6912\u20136924 (2023).<\/li>\n
    6. Chee Wezen, X. et al. Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors. J. Chem. Inf. Model. 62, 2586\u20132599 (2022).<\/li>\n<\/ol>\n","protected":false},"featured_media":6155,"parent":0,"menu_order":35,"template":"","faculty_category":[12,58],"class_list":["post-6154","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"\nXavier Chee Wezen - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/xavier-chee-wezen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Xavier Chee Wezen - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Affiliation Lecturer, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS   Education Institution and Location Year(s) Ph.D. Pharmacology,...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/xavier-chee-wezen\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-30T12:45:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2024\/09\/xavierchee.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"397\" \/>\n\t<meta property=\"og:image:height\" content=\"579\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/xavier-chee-wezen\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/xavier-chee-wezen\/\",\"name\":\"Xavier Chee Wezen - 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