{"id":6064,"date":"2024-09-18T16:46:16","date_gmt":"2024-09-18T08:46:16","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&p=6064"},"modified":"2024-09-30T20:37:42","modified_gmt":"2024-09-30T12:37:42","slug":"jiao-chunlei","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jiao-chunlei\/","title":{"rendered":"Jiao Chunlei"},"content":{"rendered":"

Affiliations<\/h3>\n

Assistant Professor, Department of Biological Sciences, Faculty of Science, NUS<\/p>\n

Joint Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS<\/p>\n

 <\/p>\n

Education<\/h3>\n\n\n\n\n\n\n
Institution and Location<\/strong><\/td>\nYear(s)<\/strong><\/td>\n<\/tr>\n
Ph.D., Infection and Immunity, Helmholtz Institute for RNA-based Infection Research (HIRI), Germany<\/td>\n2022<\/td>\n<\/tr>\n
M.Sc., Microbiology, Shandong University, China<\/td>\n2015<\/td>\n<\/tr>\n
B.Sc. Biotechnology, Henan Polytechnic University, China<\/td>\n2012<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Professional Experience<\/h3>\n\n\n\n\n\n\n\n
Institution and Location<\/strong><\/td>\nYear(s)<\/strong><\/td>\n<\/tr>\n
Assistant Professor, Presidential Young Professorship, National University of Singapore<\/td>\n2024 – Present<\/td>\n<\/tr>\n
Postdoc., Helmholtz Institute for RNA-based Infection Research (HIRI), Germany<\/td>\n2022 – 2024<\/td>\n<\/tr>\n
Research Engineer, Ngee Ann Polytechnic, Singapore<\/td>\n2016 – 2018<\/td>\n<\/tr>\n
Research Assistant, Shandong University, China<\/td>\n2015 – 2016<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Research Interests<\/h3>\n

Discovery, engineering, and design of CRISPR and novel bacterial defense systems with the aim of developing innovative platforms for disease diagnosis and treatment.<\/p>\n

 <\/p>\n

Current Research Projects<\/h3>\n
    \n
  • Develop a sensitive and high-throughput RNA detection platform<\/li>\n
  • Develop a precise and high efficient knock-in platform in eukaryotic cells<\/li>\n
  • Develop a precise and non-cytotoxic RNA knock-down platform<\/li>\n
  • Develop a long-range genome knock-out platform<\/li>\n
  • Develop a spatial RNA recording platform<\/li>\n<\/ul>\n

     <\/p>\n

    Selected Publications<\/h3>\n
      \n
    1. Jiao, C<\/strong>., Peeck, N.L., Yu, J., Ghaem Maghami, M., Kono, S., Collias, D., Martinez Diaz, S.L., Larose, R. and Beisel, C.L., 2024. TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases. Nature Communications, 15(1), p.5909.<\/li>\n
    2. Jiao, C.<\/strong>, Reckstadt, C., K\u00f6nig, F., Homberger, C., Yu, J., Vogel, J., Westermann, A.J., Sharma, C.M. and Beisel, C.L., 2023. RNA recording in single bacterial cells using reprogrammed tracrRNAs. Nature biotechnology, 41(8), pp.1107-1116.<\/li>\n
    3. Jiao, C.<\/strong> and Beisel, C.L., 2022. Reprogramming TracrRNAs for Multiplexed RNA Detection. In Riboregulator Design and Analysis (pp. 217-235). New York, NY: Springer US.<\/li>\n
    4. Jiao, C.<\/strong>, Sharma, S., Dugar, G., Peeck, N.L., Bischler, T., Wimmer, F., Yu, Y., Barquist, L., Schoen, C., Kurzai, O. and Sharma, C.M., 2021. Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9. Science, 372(6545), pp.941-948.<\/li>\n
    5. Hou, J.#, Jiao, C.<\/strong>#, Peng, B., Shen, Y. and Bao, X., 2016. Mutation of a regulator Ask10p improves xylose isomerase activity through up-regulation of molecular chaperones in Saccharomyces cerevisiae. Metabolic Engineering, 38, pp.241-250. (#, co-first author)<\/li>\n
    6. Hou, J., Shen, Y., Jiao, C.<\/strong>, Ge, R., Zhang, X. and Bao, X., 2016. Characterization and evolution of xylose isomerase screened from the bovine rumen metagenome in Saccharomyces cerevisiae. Journal of bioscience and bioengineering, 121(2), pp.160-165.<\/li>\n<\/ol>\n

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