{"id":560,"date":"2020-01-23T03:54:15","date_gmt":"2020-01-23T03:54:15","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&p=560"},"modified":"2024-09-30T20:42:44","modified_gmt":"2024-09-30T12:42:44","slug":"long-yun-chau","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/long-yun-chau\/","title":{"rendered":"Long Yun Chau"},"content":{"rendered":"

Affiliations<\/h3>\n

Senior Lecturer, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.<\/p>\n

Education<\/h3>\n\n\n\n\n\n\n\n
Degree and Institution<\/b><\/td>\nYear(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n
PhD, Karolinska Institute, Sweden<\/td>\n2007<\/td>\n<\/tr>\n
MSc, National University of Singapore<\/td>\n2002<\/td>\n<\/tr>\n
BSc, National University of Singapore<\/td>\n1996<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Professional Experience<\/h3>\n\n\n\n\n\n\n\n\n\n
Position and Institute<\/b><\/td>\nYear(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n
Senior Lecturer, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.<\/td>\n2017 \u2013 present<\/td>\n<\/tr>\n<\/tbody>\n
Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.<\/td>\n2011 \u2013 2017<\/td>\n<\/tr>\n
Research Scientist, Division of Endocrinology, Lilly Research Laboratories, Eli Lilly Corporate Center USA<\/td>\n2010 \u2013 2011<\/td>\n<\/tr>\n
Post-doctoral Fellow, Howard Hughes Medical Institute, Children\u2019s Hospital Boston, Harvard Medical School
\nUSA<\/td>\n		2007 \u2013 2009<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Research Interest<\/h3>\n

* Insulin\/ insulin-like growth factor signaling and cellular nutrient sensing.
\n* Regulation of energy substrates utilization and its role in cellular signaling.
\n* Transcriptional regulation of metabolic network and gene expression.
\n* Role of NAD\/ NADH metabolism in nutrient-gene communication.
\n* Implications of altered metabolic program in skeletal muscle and metabolic disorders such as insulin resistance and diabetes.<\/p>\n

Selected Publications<\/h3>\n
    \n
  1. Yu X,\u00a0<\/span>Long YC<\/b>. Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response.\u00a0<\/span>FASEB J<\/i>. 2014 Nov 5. pii: fj.14-252841.<\/li>\n
  2. Long YC<\/b>, Tan TM, Takao I, Tang BL. The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling.\u00a0<\/span>Am J Physiol Endocrinol Metab<\/i>. 2014; 306(6):E581-91.<\/li>\n
  3. Raichur S, Teh SH, Ohwaki K, Gaur V,\u00a0<\/span>Long YC<\/b>, Hargreaves M, McGee SL, Kusunoki J. Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells.\u00a0<\/span>J Mol Endocrinol.<\/i>\u00a0<\/span>2012; 49(3):203-11<\/li>\n
  4. Long YC<\/b>, Kharitonenkov A. Hormone-like fibroblast growth factors and metabolic regulation.\u00a0<\/span>Biochim Biophys Acta<\/i>. 2011;1812(7):791-5.<\/li>\n
  5. Long YC<\/b>, Kostovski E, Boon H, Hjeltnes N, Krook A, and Ulrika Widegren. Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects.\u00a0<\/span>J Appl Physiol<\/i>. 2011; 110(5):1204-10.<\/li>\n
  6. Long YC<\/b>, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via Akt and AMPK pathways.\u00a0<\/span>Mol Cell Biol<\/i>. 2011; 31(3):430-41.<\/li>\n<\/ol>\n","protected":false},"featured_media":428,"parent":0,"menu_order":19,"template":"","faculty_category":[12,58],"class_list":["post-560","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"\nLong Yun Chau - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/long-yun-chau\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Long Yun Chau - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Affiliations Senior Lecturer, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS. 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