{"id":554,"date":"2020-01-23T03:32:57","date_gmt":"2020-01-23T03:32:57","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&#038;p=554"},"modified":"2024-09-30T20:36:17","modified_gmt":"2024-09-30T12:36:17","slug":"jan-gruber","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/","title":{"rendered":"Jan Gruber"},"content":{"rendered":"<h3>Affiliations<\/h3>\n<p align=\"justify\">Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.<br \/>\nAssociate Professor, Yale-NUS<\/p>\n<h3>Education<\/h3>\n<table width=\"100%\">\n<thead>\n<tr>\n<td><b>Degree and Institution<\/b><\/td>\n<td width=\"100\"><b>Year(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Doctor of Philosophy in Biochemistry, University of Oxford, Laboratory of Molecular Biophysics<\/td>\n<td>2000-2004<\/td>\n<\/tr>\n<tr>\n<td>Master of Science (by Research) University of Oxford, Laboratory of Molecular Biophysics<\/td>\n<td>2000<\/td>\n<\/tr>\n<tr>\n<td>Master of Advanced Studies (Part III of the Math. Tripos) University of Cambridge, Department of Applied Mathematics and Theoretical Physics<\/td>\n<td>1998-1999<\/td>\n<\/tr>\n<tr>\n<td>Physics Vordiplom (1997) RWTH-Aachen<\/td>\n<td>1996-1997<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Professional Experience<\/h3>\n<table width=\"100%\">\n<thead>\n<tr>\n<td><b>Position and Institute<\/b><\/td>\n<td width=\"100\"><b>Year(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Assistant Professor, Department of Biochemistry, NUS Medicine<\/td>\n<td>2014\u2013present<\/td>\n<\/tr>\n<tr>\n<td>Assistant Professor, Yale-NUS Science Division<\/td>\n<td>2014\u2013present<\/td>\n<\/tr>\n<tr>\n<td>Senior Research Fellow, National University of Singapore<\/td>\n<td>2011-2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Research Interest<\/h3>\n<p align=\"justify\"><b>Jan Gruber\u2019s laboratory focuses on:<\/b><br \/>\nAgeing, Age-dependent dieseases, Interventions against<br \/>\nBasic \/ Molecular Mechanisms of Ageing<br \/>\n<i>C. elegans<\/i><span>\u00a0<\/span>as a Model Organism<br \/>\nRole of Mitochondria and Free Radicals in Ageing and Age-dependent Diseases<br \/>\nBiomarkers of Oxidative Damage<br \/>\nComputational Biology<br \/>\nEvolution of ageing<\/p>\n<h3>Selected Publications<\/h3>\n<ol class=\"ol-listing\">\n<li>Ng, L.F.,<span>\u00a0<\/span><b>Gruber, J.<\/b>, Cheah, I.K., (&#8230;), Wenk, M.R., Halliwell, B., he mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease,<span>\u00a0<\/span><i>FRBM<\/i>, (2014), 71, pp. 390-401<\/li>\n<li>Ranjan, M.,<span>\u00a0<\/span><b>Gruber, J.<\/b>, Ng, L.F., Halliwell, B., Repression of the mitochondrial peroxiredoxin antioxidant system does not shorten life span but causes reduced fitness in C. elegans.<span>\u00a0<\/span><i>FRBM<\/i><span>\u00a0<\/span>(2013), 63, pp. 381-389<\/li>\n<li><b>Gruber, J.<\/b>, Ng, L.F., Fong, S., Wong, W.T., Chen, C.B., Shui, G., Chong, W.F., Schaffer, S., Wenk, M., Halliwell, B., Mitochondrial ageing in Caenorhabditis &#8211; what do we learn from superoxide dismutase knockouts?,<span>\u00a0<\/span><i>PLoS One<\/i><span>\u00a0<\/span>(2011), e19444, p.1-16<\/li>\n<li>Pun, P.B.L.*,<span>\u00a0<\/span><b>Gruber, J.<\/b>*, Tang, S.Y., Schaffer, S., Ong, R.L.S., Fong, S., Ng, L.F., Cheah, I., Halliwell, B., Ageing in nematodes: Do antioxidants extend lifespan in Caenorhabditis elegans?, (2010)<span>\u00a0<\/span><i>Biogerontology<\/i>, 11 (1), pp. 17-30.<\/li>\n<li><b>Gruber, J.<\/b>, Tang, S.Y., Jenner, A.M., Mudway, I., Blomberg, A., Behndig, A., Kasiman, K., (&#8230;), Halliwell, B. Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: Avoiding artifacts and establishing real in vivo concentrations (2009)<span>\u00a0<\/span><i>Antioxidants and Redox Signalling<\/i>, 11 (8) PP. 1767 &#8211; 1776<\/li>\n<\/ol>\n","protected":false},"featured_media":183,"parent":0,"menu_order":11,"template":"","faculty_category":[12,58],"class_list":["post-554","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Jan Gruber - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jan Gruber - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Affiliations Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS. Associate Professor, Yale-NUS Education Degree and Institution...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-30T12:36:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2020\/01\/team-5-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"277\" \/>\n\t<meta property=\"og:image:height\" content=\"404\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/\",\"name\":\"Jan Gruber - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/#website\"},\"datePublished\":\"2020-01-23T03:32:57+00:00\",\"dateModified\":\"2024-09-30T12:36:17+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/medicine.nus.edu.sg\/bch\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Jan Gruber\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/#website\",\"url\":\"https:\/\/medicine.nus.edu.sg\/bch\/\",\"name\":\"Department of Biochemistry \u2013 School of Medicine, National University of Singapore\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/medicine.nus.edu.sg\/bch\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Jan Gruber - Department of Biochemistry \u2013 School of Medicine, National University of Singapore","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/","og_locale":"en_US","og_type":"article","og_title":"Jan Gruber - Department of Biochemistry \u2013 School of Medicine, National University of Singapore","og_description":"Affiliations Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS. Associate Professor, Yale-NUS Education Degree and Institution...","og_url":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/","og_site_name":"Department of Biochemistry \u2013 School of Medicine, National University of Singapore","article_modified_time":"2024-09-30T12:36:17+00:00","og_image":[{"width":277,"height":404,"url":"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2020\/01\/team-5-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/","url":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/","name":"Jan Gruber - Department of Biochemistry \u2013 School of Medicine, National University of Singapore","isPartOf":{"@id":"https:\/\/medicine.nus.edu.sg\/bch\/#website"},"datePublished":"2020-01-23T03:32:57+00:00","dateModified":"2024-09-30T12:36:17+00:00","breadcrumb":{"@id":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/jan-gruber\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medicine.nus.edu.sg\/bch\/"},{"@type":"ListItem","position":2,"name":"Jan Gruber"}]},{"@type":"WebSite","@id":"https:\/\/medicine.nus.edu.sg\/bch\/#website","url":"https:\/\/medicine.nus.edu.sg\/bch\/","name":"Department of Biochemistry \u2013 School of Medicine, National University of Singapore","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medicine.nus.edu.sg\/bch\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/medicine.nus.edu.sg\/bch\/wp-json\/wp\/v2\/faculty\/554","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.nus.edu.sg\/bch\/wp-json\/wp\/v2\/faculty"}],"about":[{"href":"https:\/\/medicine.nus.edu.sg\/bch\/wp-json\/wp\/v2\/types\/faculty"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/bch\/wp-json\/wp\/v2\/media\/183"}],"wp:attachment":[{"href":"https:\/\/medicine.nus.edu.sg\/bch\/wp-json\/wp\/v2\/media?parent=554"}],"wp:term":[{"taxonomy":"faculty_category","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/bch\/wp-json\/wp\/v2\/faculty_category?post=554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}