{"id":546,"date":"2020-01-23T03:17:10","date_gmt":"2020-01-23T03:17:10","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&p=546"},"modified":"2024-09-30T20:44:12","modified_gmt":"2024-09-30T12:44:12","slug":"tang-bor-luen","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/tang-bor-luen\/","title":{"rendered":"Tang Bor Luen"},"content":{"rendered":"

Affiliations<\/h3>\n

Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
\nDeputy Executive Director, NUS Graduate School for Integrative Sciences and Engineering (NGS)<\/p>\n

Education<\/h3>\n\n\n\n\n\n\n
Degree and Institution<\/b><\/td>\nYear(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n
PhD, National University of Singapore<\/td>\n1994<\/td>\n<\/tr>\n
MSc, National University of Singapore<\/td>\n1988<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Professional Experience<\/h3>\n\n\n\n\n\n\n\n
Position and Institute<\/b><\/td>\nYear(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n
Associate Professor, Department of Biochemistry, NUS<\/td>\n2001-present<\/td>\n<\/tr>\n
Deputy Executive Director, NUS Graduate School for Integrative Sciences and Engineering (NGS), NUS<\/td>\n2011-present<\/td>\n<\/tr>\n
Research Fellow\/Research Associate, Institute of Molecular and Cell Biology, Singapore<\/td>\n1994-2001<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Research Interest<\/h3>\n
    \n
  • Small GTPases, SNAREs and cell adhesion molecules and their cellular and physiological roles in CNS neurons and glia.<\/li>\n
  • Conventional and unconventional membrane trafficking components and mechanisms in bacterial and viral infection.<\/li>\n
  • Sirtuins in neurodegeneration and aging.<\/li>\n<\/ul>\n

    Selected Publications<\/h3>\n
      \n
    1. Lim YS and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2015) A novel role for Rab23 in the trafficking of Kif17 to the primary cilia.\u00a0<\/span>J Cell Sci<\/i>. (in press).<\/li>\n
    2. Chua CE and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2015) Role of Rab GTPases and their interacting proteins in mediating metabolic signalling and regulation.\u00a0<\/span>Cell. Mol. Life Sci.<\/i>\u00a0<\/span>72: 2289-2304.<\/li>\n
    3. Ng F, Laura W and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2015) SIRT1 in the brain-Connections with aging-associated disorders and lifespan.\u00a0<\/span>Front Cell Neurosci<\/i>. 9: 64. doi: 10.3389\/fncel.2015.00064.<\/li>\n
    4. Chua CE and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2015) The role of the small GTPase Rab31 in cancer.\u00a0<\/span>J. Cell Mol. Med.<\/i>\u00a0<\/span>19: 1-10.<\/li>\n
    5. Chua CE and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2014) Rab31 is expressed in Neural Progenitor Cells and plays a role in their differentiation.\u00a0<\/span>FEBS Lett.<\/i>\u00a0<\/span>588: 3186-3194.<\/li>\n
    6. Chua CE and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2014) Engagement of the Small GTPase Rab31 and its effector, Early Endosome Antigen 1, is Important for trafficking of ligand-bound Epidermal Growth Factor Receptor from early to late endosome.\u00a0<\/span>J. Biol. Chem.<\/i>\u00a0<\/span>289: 12375-12389.<\/li>\n
    7. Chua CE, Chan SN and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2014) Non-cell autonomous or secretory tumor suppression.\u00a0<\/span>J. Cell Physiol<\/i>. 229: 1346-1352.<\/li>\n
    8. Long YC, Tan TM, Inoue T and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2014) The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signalling. Am.\u00a0<\/span>J. Physiol. Endocrinol. Metab<\/i>. 306: E581-591.<\/li>\n
    9. B\u00e9guin P, Nagashima K, Mahalakshmi RN Vigot R, Matsunaga A, Miki T, Ng MY, Ng AY, Lim CH, Tay HS, Hwang LA, Firsov D,\u00a0<\/span>Tang BL<\/b>, Inagaki N, Mori Y, Seino S, Launey T, and Hunziker W (2014) BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis.\u00a0<\/span>J. Cell Biol.<\/i>\u00a0<\/span>205: 233-249.<\/li>\n
    10. Teng FY and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2013) Nogo\/RTN4 isoforms and RTN3 expression protect SH-SY5Y cells against multiple death insults.\u00a0<\/span>Mol. Cell Biochem<\/i>. 384: 7-19.<\/li>\n
    11. Ng F and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2013) Sirtuins\u2019 modulation of autophagy.\u00a0<\/span>J. Cell. Physiol.<\/i>\u00a0<\/span>228: 2262-2270.<\/li>\n
    12. Chua CE, Lim YS, Lee MG,\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2012) Non-classical membrane trafficking processes galore.\u00a0<\/span>J. Cell Physiol.<\/i>\u00a0<\/span>227: 3722-3730.<\/li>\n
    13. Chen Y, Hor HH and\u00a0<\/span>Tang BL<\/b>. (2012) AMIGO is expressed in multiple brain cells types and may regulate dendritic growth and neuronal survival.\u00a0<\/span>J. Cell Physiol<\/i>. 227: 2217-2229.<\/li>\n
    14. Gee HY, Roh SH,\u00a0<\/span>Tang BL<\/b>, Kim KH, and Lee MG. (2011) Rescue of \u0394F508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.Cell<\/i>\u00a0<\/span>146: 746-760.<\/li>\n
    15. Chua CE, Gan BQ and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2011) Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation.\u00a0<\/span>Cell Mol. Life Sci.<\/i>\u00a0<\/span>68: 3349-3358.<\/li>\n
    16. Chua CE and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2011) Rabs, SNAREs and \u03b1-synuclein-membrane trafficking defects in synucleinopathies.\u00a0<\/span>Brain Res.<\/i>\u00a0<\/span>Rev. 67: 268-281.<\/li>\n
    17. Lim YS, Chua CE and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2011) Rabs and other small GTPases in ciliary transport.\u00a0<\/span>Biol. Cell\u00a0<\/span><\/i>103: 209-221.<\/li>\n
    18. Tang BL<\/b>, Gee HY and Lee MG (2011) The cystic fibrosis transmembrane conductance regulator (CFTR)\u2019s expanding SNARE interactome.\u00a0<\/span>Traffic\u00a0<\/span><\/i>12: 364-371.<\/li>\n
    19. Tang BL<\/b>\u00a0<\/span>(2011) Sirt1’s systemic protective roles and its promise as a target in anti-aging medicine.\u00a0<\/span>Trans. Res<\/i>. 157: 276-284.<\/li>\n
    20. Gee HY,\u00a0<\/span>Tang BL<\/b>, Kim KH and Lee MG (2010) Syntaxin 16 binds to CFTR and regulates its membrane trafficking in epithelial cells.\u00a0<\/span>J. Biol. Chem<\/i>. 285: 35519-35527.<\/li>\n
    21. Meng J, Xia W, Tang J,\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>and Liang F (2010) Dephosphorylation dependent inhibitory activity of juxtanodin on filamentous actin disassembly.\u00a0<\/span>J. Biol. Chem.\u00a0<\/span><\/i>285: 28838-28849.<\/li>\n
    22. Ong YS,\u00a0<\/span>Tang BL<\/b>, Loo LS and Hong W (2010) p125A exists as part of the mammalian Sec13-Sec31 COPII subcomplex to facilitate ER-Golgi transport,\u00a0<\/span>J. Cell Biol.\u00a0<\/span><\/i>190: 331-345.<\/li>\n
    23. Chen Y, Gan BQ and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2010) Syntaxin 16: unravelling cellular physiology through a ubiquitous SNARE molecule.\u00a0<\/span>J. Cell. Physiol.\u00a0<\/span><\/i>225:326-332.<\/li>\n
    24. Gan BQ and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2010) Sirt1\u2019s beneficial roles in neurodegenerative diseases \u2013 a CCT connection?\u00a0<\/span>Aging Cell<\/i>\u00a0<\/span>9:924-929.<\/li>\n
    25. Chua CE, Lim YS and\u00a0<\/span>Tang BL<\/b>\u00a0<\/span>(2010) Rab35 \u2013 a vesicular traffic regulating small GTPase with actin modulating roles,\u00a0<\/span>FEBS Lett.<\/i>\u00a0<\/span>584: 1-6.<\/li>\n<\/ol>\n","protected":false},"featured_media":548,"parent":0,"menu_order":29,"template":"","faculty_category":[12,58],"class_list":["post-546","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"\nTang Bor Luen - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/tang-bor-luen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tang Bor Luen - 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