{"id":542,"date":"2020-01-23T03:05:41","date_gmt":"2020-01-23T03:05:41","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&#038;p=542"},"modified":"2024-09-30T20:44:37","modified_gmt":"2024-09-30T12:44:37","slug":"thilo-hagen","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/thilo-hagen\/","title":{"rendered":"Thilo Hagen"},"content":{"rendered":"<h3>Affiliations<\/h3>\n<p align=\"justify\">Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.<br \/>\nSupervisor, NUS Graduate School for Integrative Sciences and Engineering (NGS).<\/p>\n<h3>Education<\/h3>\n<table width=\"100%\">\n<thead>\n<tr>\n<td><b>Degree and Institution<\/b><\/td>\n<td width=\"100\"><b>Year(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>M.D. Humboldt University Berlin<\/td>\n<td>1996<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Professional Experience<\/h3>\n<table width=\"100%\">\n<thead>\n<tr>\n<td><b>Position and Institute<\/b><\/td>\n<td width=\"100\"><b>Year(s)<\/b><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS<\/td>\n<td>2013 \u2013 present<\/td>\n<\/tr>\n<tr>\n<td>Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS<\/td>\n<td>2007 \u2013 2013<\/td>\n<\/tr>\n<tr>\n<td>Assistant Professor, Wolfson Digestive Diseases Centre, University of Nottingham, UK<\/td>\n<td>2003 \u2013 2007<\/td>\n<\/tr>\n<tr>\n<td>Postdoctoral Research Fellow. Wolfson Institute for Biomedical Research, University College London, UK<\/td>\n<td>2001 \u2013 2003<\/td>\n<\/tr>\n<tr>\n<td>Postdoctoral Research Fellow. Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline, UK<\/td>\n<td>2000 \u2013 2001<\/td>\n<\/tr>\n<tr>\n<td>Postdoctoral Research Fellow. Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA<\/td>\n<td>1998 \u2013 2000<\/td>\n<\/tr>\n<tr>\n<td>Postdoctoral Research Fellow. Departments of Genetics and Laboratory Medicine, Children\u2019s Hospital, Harvard Medical School, USA<\/td>\n<td>1996 \u2013 1998<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Research Interest<\/h3>\n<p align=\"justify\">* Cellular signaling and energy metabolism<br \/>\n* Cellular stress response<br \/>\n* Novel therapeutic approaches for obesity and cancer<\/p>\n<h3>Selected Publications<\/h3>\n<ol class=\"ol-listing\">\n<li>SY Hong, T Hagen. Multiple myeloma Leu167Ile (c.499C&gt;A) mutation prevents XBP1 mRNA splicing.<span>\u00a0<\/span><i>Br. J. Haematol<\/i>. 161:898-901 (2013)<\/li>\n<li>L Cordero-Espinoza,<span>\u00a0<\/span><u>T Hagen<\/u>. Increased concentrations of Fructose-2,6-bisphosphate contribute to the Warburg effect in PTEN-deficient cells.<span>\u00a0<\/span><i>J. Biol. Chem.<\/i><span>\u00a0<\/span>288:36020-36008 (2013)<\/li>\n<li>SY Hong, FX Yu, Y Luo,<u>T Hagen<\/u>. Oncogenic activation of the PI3K\/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein.<span>\u00a0<\/span><i>Cell. Signal.<\/i><span>\u00a0<\/span>28:377-83 (2016)<\/li>\n<li>SY Hong, LT Ng, LF Ng, T Inoue, NS Tolwinski,<span>\u00a0<\/span><u>T Hagen<\/u>\u00b6, J Gruber\u00b6. The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing.<span>\u00a0<\/span><i>PLoS One<\/i><span>\u00a0<\/span>11:e0168752 (2016)<\/li>\n<li>MY Ng, M Wang, PJ Casey, YH Gan, T Hagen. Activation of MAPK\/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).<span>\u00a0<\/span><i>PLoS One<\/i><span>\u00a0<\/span>12:e0171464 (2017)<\/li>\n<li>DPW Wong, MY Ng, JY Leung, BK Boh, EC Lim, SH Tan, S Lim, WH Seah, CZ Hu, BC Ho, DHP Ng, T Hagen. Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes.<span>\u00a0<\/span><i>PLoS One<\/i><span>\u00a0<\/span>13:e0204853. (2018)<\/li>\n<\/ol>\n","protected":false},"featured_media":433,"parent":0,"menu_order":32,"template":"","faculty_category":[12,58],"class_list":["post-542","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Thilo Hagen - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/thilo-hagen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thilo Hagen - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Affiliations Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS. 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