{"id":3947,"date":"2023-01-26T14:41:31","date_gmt":"2023-01-26T06:41:31","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&p=3947"},"modified":"2024-09-30T20:45:12","modified_gmt":"2024-09-30T12:45:12","slug":"vincenzo-sorrentino","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/vincenzo-sorrentino\/","title":{"rendered":"Vincenzo Sorrentino"},"content":{"rendered":"

Affiliations<\/h3>\n

Assistant Professor, Department of Biochemistry & Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, NUS<\/p>\n

Biodata<\/h3>\n

Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam, in the lab of Prof. Noam Zelcer, on LDL-cholesterol regulation by the ubiquitin-proteasome system, with publications including in European Heart Journal and Circulation Research. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx\u2019s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging, with his research discoveries on Alzheimer\u2019s disease and muscle aging published in Nature (2017) and Cell Reports (2021). He then obtained a position as Group Leader at the Nestl\u00e9 Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.<\/p>\n

Education<\/h3>\n\n\n\n\n
Degree and Institution<\/strong><\/td>\nYear(s)<\/strong><\/td>\n<\/tr>\n
PhD cum Laude<\/em> in Medical Biochemistry, University of Amsterdam<\/td>\n2010 – 2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Professional Experience<\/h3>\n\n\n\n\n\n\n
Position and Institute<\/strong><\/td>\nYear(s)<\/strong><\/td>\n<\/tr>\n
Assistant Professor, Department of Biochemistry & Healthy Longevity TRP, YLLSoM, NUS<\/td>\nDec 2022 – Present<\/td>\n<\/tr>\n
Group Leader, Nestle’ Institute of Health Sciences, Switzerland<\/td>\n2019 – 2022<\/td>\n<\/tr>\n
Postdoctoral Fellow, Auwerx Lab, EPFL, Switzerland<\/td>\n2015 – 2018<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Research Interest<\/h3>\n

Biology of aging with a focus on the interconnection between mitochondrial homeostasis and proteostasis.<\/p>\n

Current Research Projects<\/h3>\n

The projects explore the interconnectivity and possible therapeutic targeting of the cellular hallmarks of the aging process, with a particular focus on mitochondrial dysfunction, protein aggregation and alterations of NAD+ metabolism. Dr. Vincenzo Sorrentino\u2019s recent work was pivotal in establishing a functional and druggable interdependence between mitochondrial stress response pathways, NAD+ boosting and amyloid aggregation in Alzheimer\u2019s disease (Nature, 2017 DOI: 10.1038\/nature25143) and muscle aging (Cell Reports 2021, DOI: 10.1016\/j.celrep.2020.108660). Several projects are currently open in the Sorrentino\u2019s laboratory:<\/p>\n

    \n
  1. Characterization of a novel NAD+ precursor for muscle and brain health in aging<\/li>\n
  2. Dissecting cellular pathways of aging- and senescence-associated amyloidosis<\/li>\n
  3. Elucidation of common proteotoxic stress response signatures across aging and age-related diseases<\/li>\n<\/ol>\n

     <\/p>\n

    PI\u2019s laboratory focuses on:<\/p>\n

      \n
    1. Biology of aging<\/li>\n
    2. Proteostasis<\/li>\n
    3. Mitochondria and NAD+ metabolism<\/li>\n
    4. Preclinical models of neuromuscular disease (e.g. C. elegans<\/em>, cell lines, rodents)<\/li>\n<\/ol>\n

       <\/p>\n

      Selected Publications<\/h3>\n

      # correspondence; * equal contribution<\/strong><\/span><\/p>\n

        \n
      1. Membrez M, Migliavacca E, Christen S, Trieu J, Lee AK, Giner MP, Morandini F, Makarov MV, Garratt ES, Canto C, Karagounis L, Migaud ME, Karnani N, Tay SKH, Lillycrop KA, Godfrey KM, Moco S, Koopman R, Lynch GS, Sorrentino V#<\/strong><\/span>, Feige JN# Trigonelline is a Novel NAD+ Precursor Reduced in Human Sarcopenia which Improves Muscle function during Aging. Nature Metabolism, in revision (2023<\/strong>)<\/strong><\/em><\/li>\n
      2. Burtscher J#, Romani M, Bernardo G, Traian P, Ziviani E, Hummel F, Millet G, Sorrentino V#<\/strong><\/span>. Boosting mitochondrial resilience to counteract neurodegeneration. Progress in Neurobiology, <\/strong><\/em>2022<\/strong>; doi.org\/10.1016\/j.pneurobio.2022.102289<\/li>\n
      3. Romani M*, Sorrentino V*<\/strong><\/span>, Chamgyung O, Li H, Zhang H, Shong M, Auwerx J. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Reports, <\/strong><\/em>2021<\/strong>; 34(3):108660. doi: 10.1016\/j.celrep.2020.108660<\/li>\n
      4. Sorrentino V<\/strong><\/span>, Romani M, Mouchiroud L, Beck JS, Zhang H, D’Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J. Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity. Nature <\/strong><\/em>2017<\/strong>; 552(7684):187-193. doi: 10.1038\/nature25143.<\/li>\n
      5. Sorrentino V*<\/strong><\/span>, Nelson J*, Avagliano Trezza R, Heride C, Urb\u00e8 S, Distel B, Zelcer N. USP2 positively regulates the LDLR pathway through deubiquitylation of the E3-ubiquitin ligase IDOL. Circulation Research. <\/strong><\/em>2015<\/strong> doi:10.1161\/CIRCRESAHA.115.30729<\/li>\n<\/ol>\n","protected":false},"featured_media":3948,"parent":0,"menu_order":34,"template":"","faculty_category":[12,58],"class_list":["post-3947","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"\nVincenzo Sorrentino - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/vincenzo-sorrentino\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vincenzo Sorrentino - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Affiliations Assistant Professor, Department of Biochemistry & Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, NUS Biodata...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/vincenzo-sorrentino\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-30T12:45:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2023\/01\/Photo-Sorrentino.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"397\" \/>\n\t<meta property=\"og:image:height\" content=\"579\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/vincenzo-sorrentino\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/vincenzo-sorrentino\/\",\"name\":\"Vincenzo Sorrentino - 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