{"id":3342,"date":"2022-04-06T13:12:21","date_gmt":"2022-04-06T05:12:21","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&#038;p=3342"},"modified":"2024-09-30T20:43:15","modified_gmt":"2024-09-30T12:43:15","slug":"shi-jiahai","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/shi-jiahai\/","title":{"rendered":"Shi Jiahai"},"content":{"rendered":"<h3>Affliations<\/h3>\n<p>Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.<\/p>\n<p>Principal Investigator, NUS Medicine Synthetic Biology Translational Research Programme<\/p>\n<h3>Education<\/h3>\n<table style=\"border-collapse: collapse; width: 100%; height: 58px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 68.6367%; height: 24px;\"><strong>Institution and Location<\/strong><\/td>\n<td style=\"width: 31.3633%; height: 24px;\"><strong>Year(s)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 10px;\">\n<td style=\"width: 68.6367%; height: 10px;\">Bachelor of Science, Xiamen University, China<\/td>\n<td style=\"width: 31.3633%; height: 10px;\">1998 &#8211; 2002<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 68.6367%; height: 24px;\">Ph.D. , National University of Singapore, Singapore<\/td>\n<td style=\"width: 31.3633%; height: 24px;\">2003 &#8211; 2008<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Professional Experience<\/h3>\n<table style=\"border-collapse: collapse; width: 100%; height: 96px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 68.6367%; height: 24px;\"><strong>Institution and Location<\/strong><\/td>\n<td style=\"width: 31.3633%; height: 24px;\"><strong>Year(s)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 68.6367%; height: 24px;\"><span lang=\"EN-SG\">Post-doc, National University of Singapore, Singapore<\/span><\/td>\n<td style=\"width: 31.3633%; height: 24px;\"><span lang=\"EN-SG\">2008-2010<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 68.6367%; height: 24px;\"><span lang=\"EN-SG\">Post-doc,<\/span><span lang=\"EN-SG\"> <\/span><span lang=\"EN-SG\">Massachusetts Institute of Technology\/Whitehead Institute for Biomedical Sciences, US <\/span><\/td>\n<td style=\"width: 31.3633%; height: 24px;\">2010-2015<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 68.6367%; height: 24px;\">Assistant\/Associate Professor, City University of Hong Kong, Hong Kong<\/td>\n<td style=\"width: 31.3633%; height: 24px;\">2015-2021<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Research Interest<\/h3>\n<p>Red blood cell biogenesis<\/p>\n<p>Red cell therapy and gene therapy<\/p>\n<h3>Current Research Projects<\/h3>\n<p>Mechanistic study of terminal erythropoiesis<\/p>\n<p>Gene therapy in hematopoietic stem cells against blood disorders and metabolic diseases<\/p>\n<h3>Selected Publications<\/h3>\n<ol>\n<li>Dong H, Zhang Y, Wang J, Xiang H, Lv T, Wei L, Yang S, Liu X, Ren B, Zhang X, Liu L, Cao J, Wang M,<strong> Shi J<\/strong>#, Yang N#., \u201cCas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci.\u201d, <strong>J Immunol<\/strong>. 2022 Jan 1;208(1):181-189. doi: 10.4049\/jimmunol.2100844., (#: co-corresponding author)<\/li>\n<li>Wei L, Wang M, Xiang H, Jiang Y, Gong J, Su D, Al Azad MAR, Dong H, Feng L, Wu J, Chan LL, Yang N#, <strong>Shi J<\/strong>#, \u201cBamboo Shark as a Small Animal Model for Single Domain Antibody Production.\u201d, <strong>Front Bioeng Biotechnol.<\/strong> 2021 Dec 8;9:792111. doi: 10.3389\/fbioe.2021.792111. (#: co-corresponding author)<\/li>\n<li>Panbing Wang, M. A. R. Al Azad, Xiong Yang, Paolo R. Martelli, Kam Yan Cheung,<strong> Jiahai Shi<\/strong>#, Yajing Shen#, \u201cSelf-adaptive and efficient propulsion of Ray sperms at different viscosities enabled by heterogeneous dual helixes.\u201d <strong>Proc Natl Acad Sci U S A<\/strong>. 2021, accepted, (#: co-corresponding author)<\/li>\n<li>Pham TC, Jayasinghe MK, Pham TT, Yang Y, Wei L, Usman WM, Chen H, Pirisinu M, Gong J, Kim S, Peng B, Wang W, Chan C, Ma V, Nguyen NTH, Kappei D, Nguyen XH, Cho WC, <strong>Shi J<\/strong>#, Le MTN#, \u201cCovalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery.\u201d <strong>J Extracell Vesicles<\/strong>. 2021 Feb;10(4):e12057. doi: 10.1002\/jev2.12057. Epub 2021 Feb 16. (#: co-corresponding author)<\/li>\n<li>Ru Zhen, Chingyee Moo, Zhenzhen Zhao, Mengying Chen, He Feng, Xiaojun Zheng, Liang Zhang, <strong>Jiahai Shi<\/strong>#, Caiyong Chen#, \u201cWdr26 regulates nuclear condensation in developing erythroblasts\u201d <strong>Blood,<\/strong> 2020 Jan 16;135(3):208-219. doi: 10.1182\/blood.2019002165 (#: co-corresponding author) (cover story)<\/li>\n<li>Yuanyan Tan, Athena H. Y. Chu, Siyu Bao, Duc Anh Hoang, Firaol Tamiru Kebede, Wenjun Xiong, Mingfang Ji, <strong>Jiahai Shi<\/strong>#, Zongli Zheng#, \u201cRationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity\u201d, <strong>Proc Natl Acad Sci U S A<\/strong>. 2019 Oct 15;116(42):20969-20976. doi: 10.1073\/pnas.1906843116. Epub 2019 Sep 30 (#: co-corresponding author)<\/li>\n<li><strong>Jiahai Shi<\/strong>*, Lenka Kundrat*, Novalia Pishesha, Angelina Bilate, Chris Theile, Takeshi Maruyama, Stephanie K. Dougan, Hidde Ploegh, and Harvey Lodish, \u201cEngineered red cells as carriers for systemic delivery of a wide array of functional probes\u201d, <strong>Proc Natl Acad Sci U S A<\/strong>. 2014 Jul 15;111(28):10131-6. *: Equal contribution<\/li>\n<\/ol>\n","protected":false},"featured_media":3346,"parent":0,"menu_order":24,"template":"","faculty_category":[12,58],"class_list":["post-3342","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Shi Jiahai - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/shi-jiahai\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Shi Jiahai - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Affliations Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS. 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