{"id":2960,"date":"2021-09-23T16:48:04","date_gmt":"2021-09-23T08:48:04","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?post_type=faculty&p=2960"},"modified":"2024-09-30T20:37:48","modified_gmt":"2024-09-30T12:37:48","slug":"julius-fredens","status":"publish","type":"faculty","link":"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/julius-fredens\/","title":{"rendered":"Julius Fredens"},"content":{"rendered":"

Affiliations<\/h3>\n

Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
\nPrinciple Investigator, NUS Medicine Synthetic Biology Translational Research Programme<\/p>\n

Education<\/h3>\n\n\n\n\n
Position and Institution<\/strong><\/td>\nYear(s)<\/strong><\/td>\n<\/tr>\n
Ph.D. Biochemistry and Molecular Biology, University of Southern Denmark<\/td>\n2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Professional Experience<\/h3>\n\n\n\n\n\n\n
Position and Institution<\/strong><\/td>\nYear (s)<\/strong><\/td>\n<\/tr>\n
Asst Professor, Presidential Young Professorship, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS<\/td>\n2021 – Present<\/td>\n<\/tr>\n
Research Associate, Corpus Christi College, University of Cambridge, UK<\/span><\/td>\n2015 – 2020<\/td>\n<\/tr>\n
Postdoctoral Fellow, MRC Laboratory of Molecular Biology, Cambridge, UK<\/span><\/td>\n2014 – 2021<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Research Interest<\/h3>\n

Synthetic genomics with a focus on novel applications in healthcare and biotechnology.<\/p>\n

Current Research Projects<\/h3>\n
    \n
  1. Directed evolution of bacteriophage to recognise new targets.<\/li>\n
  2. Design and construction of novel bacteriophage genomes.<\/li>\n
  3. Stability v.s. speed: Creating bioproduction strains from fast growing cyanobacteria<\/li>\n<\/ol>\n

    <\/h3>\n

    Selected Publications<\/h3>\n
      \n
    1. Robertson WE, Funke LFH, Torre Ddl, Fredens J<\/strong>, Elliott TS, Spinck M, Christova Y, Cervettini D, B\u00f6ge F, Liu KC, Buse S, Maslen S, Salmond GPC, Chin JW (2021) Sense codon reassignment enables viral resistance and encoded polymer synthesis. Science 372:1057-1062.<\/li>\n
    2. Robertson WE, Funke LFH, Torre Ddl, Fredens J<\/strong>, Wang K, Chin JW (2021) Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS. Nature Protocols 16:2345-2380.<\/li>\n
    3. Fredens J<\/strong>, Wang K, Torre Ddl, Funke LFH, Robertson WE, Christova Y, Chia T, Schmied WH, Dunkelmann DL, Ber\u00e1nek V, Uttamapinant C, Llamazares AG, Elliott TS, Chin JW (2019) Total synthesis of Escherichia coli with a recoded genome. Nature 569:514-518.<\/li>\n
    4. Wang K, Fredens J<\/strong>, Brunner SF, Kim SH, Chia T, Chin JW (2016) Defining synonymous codon compression schemes by genome recoding. Nature 539:59-64.<\/li>\n
    5. Fredens J<\/strong>, Engholm-Keller K, Giessing A, Pultz D, Larsen MR, H\u00f8jrup P, M\u00f8ller-Jensen J, F\u00e6rgeman NJ (2011) Quantitative proteomics by amino acid labeling in C. elegans. Nature Methods 8:845-847.<\/li>\n<\/ol>\n","protected":false},"featured_media":2992,"parent":0,"menu_order":14,"template":"","faculty_category":[12,58],"class_list":["post-2960","faculty","type-faculty","status-publish","has-post-thumbnail","hentry","faculty_category-academic-faculty","faculty_category-academic-faculty-academic-faculty"],"acf":[],"yoast_head":"\nJulius Fredens - Department of Biochemistry \u2013 School of Medicine, National University of Singapore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/julius-fredens\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Julius Fredens - Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"og:description\" content=\"Affiliations Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS Principle Investigator, NUS Medicine Synthetic Biology Translational...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/julius-fredens\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Biochemistry \u2013 School of Medicine, National University of Singapore\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-30T12:37:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2021\/09\/Julius-Fredens-2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"397\" \/>\n\t<meta property=\"og:image:height\" content=\"579\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/julius-fredens\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/julius-fredens\/\",\"name\":\"Julius Fredens - 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