Principal Investigator

Zhang Yongliang

Assistant Professor
Department of Microbiology
Yong Loo Lin School of Medicine

Tel:(65) 6516 6407

Zhang Yongliang's research focuses on signal transduction pathways that regulate innate and adaptive immune responses. His group in NUS utilizes mice deficient in genes known as MAP kinase phosphatases (MKPs) or dual specificity phosphatases (DUSPs) to investigate their regulatory mechanisms in inflammatory and infectious diseases including bacteria and virus infection, intestinal inflammation and obesity related metabolic disorders.

Wang X, F Zhang, F Chen, D Liu, Y Zheng, Y Zhang, C Dong, and B Su 2011. MEKK3 regulates IFN-g production in T cells through the Rac1/2-dependent MAPK cascades J Immunol 186: 5791-5800.

Nurieva R, S Zheng, W Jin, Y Chung, Y Zhang, G J Martinez, J Reynolds, S Wang, X Lin S Sun, G Lozano and C Dong 2010. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation Immunity 32: 670-680.

Reynolds J, B P Pappu, J Peng, G J Martinez, Y Zhang, Y Chung, L Ma, X O Yang, R I Nurieva, Q Tian, and C Dong 2010 Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease Immunity 32: 692-702.

Zhang Y, Reynolds J, Chang S H, Martin-Orozco N, Chung Y, Nurieva R and Dong C 2009. MAP kinase phosphatase 1 is necessary for T cell activation and function J Biol Chem 284: 30815-30824.

Nurieva R, Yang X, Martinez G, Zhang Y, Panopoulos A D, Ma L, Schlun K, Tian Q, Watowich S, Jetten A M, and Dong C 2007. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells Nature 448: 480-483.