The main focus of the laboratory is on understanding of the mechanisms of maintenance of genome integrity in humans and mice. Our research interests are:

  1. Telomere Dysfunction, DNA Repair Deficiency, Oxidative Stress and Ageing
    Telomeres are the ends of the chromosomes whose dysfunction drives the cells towards chromosome-genomic instability resulting in either ageing and/or cancer. We are exploring the role of DNA repair factors (e.g. nucleotide excision repair and base excision repair) in controlling telomere-chromosome stability and other cellular processes.

  2. Toxico-genomics/Environmental Toxicology
    The study of the cellular, physiological and molecular effects of potential environmental toxicants such as polyaromatic hydrocarbons, radiation and nanoparticles on normal human and murine cells. Currently, we are also engaged in the study of genetic susceptibility and environmental exposure to toxicants in DNA repair deficient cells.

  3. Experimental Therapeutics
    In a mechanism-based combinatorial approach, we sought to target aberrant regulators of cellular processes and function in cancer cells using two or more drugs, or radiation with drug treatment, in combination with telomerase inhibition to investigate their synergistic effects on the pathways (esp. DNA repair and damage response) that are up-regulated in cancer. We are investigating the drug candidates that inhibit telomerase and make cancer cells susceptible to radiation and drugs.


Lab photo taken in 2015

 

 

 

 

 

Last modified on 20 October, 2015