Shen Han Ming



Shen Han Ming

Educational Background: MD, MPH, PhD.

Position: Professor

Contact number/s: +65-6516 4998 (office)/ +65-6516 6406 (Lab)

Fax number: +65-6778 8161

Email address: phsshm@nus.edu.sg

Location of Office: MD9 2 Medical Drive #04-13 Singapore 117597

Location of Laboratory: MD9, #03-01

Name of Laboratory: Autophagy and Cancer Cell Biology


Research Areas of Interest:

  • Autophagy: Regulatory Mechanisms and Biological Functions in Cancer
  • Involvement of ROS and Oxidative Stress in Cell Death (Apoptotic and Non Apoptotic Cell Death)
  • Antioxidants and Natural Products as Anti-Cancer Agents

Selected Publications

  • Wang L, Cho YL, Tang Y, Wang J, Park JE, Wu Y, Wang C, Tong Y, Chawla R, Zhang J, Shi Y, Deng S, Lu G, Wu Y, Tan HW, Pawijit P, Lim GG, Chan HY, Zhang J, Fang L, Yu H, Liou YC, Karthik M, Bay BH, Lim KL, Sze SK, Yap CT, Shen HM. CPTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Res. 2018 Aug;28(8):787-802. doi: 10.1038/s41422-018-0056-0. Epub 2018 Jun 22. Erratum in: Cell Res. 2018 Jul 23.
  • Wang J, Zhang J, Lee YM, Ng S, Shi Y, Hua ZC, Lin Q, Shen HM. Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat Protoc. 2017 Dec;12(2):279-288. doi: 10.1038/nprot.2016.160. Epub 2017 Jan 12.
  • Shi Y, Tan SH, Ng S, Zhou J, Yang ND, Koo GB, McMahon KA, Parton RG, Hill MM, Del Pozo MA, Kim YS, Shen HM. Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy. Autophagy. 2015;11(5):769-84. doi: 10.1080/15548627.2015.1034411.
  • Shen HM, Mizushima N. At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy. Trends Biochem Sci. 2014 Feb;39(2):61-71. doi: 10.1016/j.tibs.2013.12.001. Epub 2013 Dec 24. Review.
  • Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 2013 Apr;23(4):508-23. doi: 10.1038/cr.2013.11. Epub 2013 Jan 22.

Awards

2015 Research Excellence Award, Yong Loo Lin School of Medicine, NUS
2011 Free Radical Biology and Medicine most cited paper 2006-2011 Award
2007 Research Excellence Award, Yong Loo Lin School of Medicine, NUS
2002 - 2003 Oncology Fellowship, National Cancer Institute (NCI), NIH, USA