Shen Han Ming



Shen Han Ming

Educational Background: MD, MPH, PhD.

Position: Professor

Contact number/s: +65-6516 4998 (office)/ +65-6516 6406 (Lab)

Fax number: +65-6778 8161

Email address: han-ming_shen@nuhs.edu.sg

Location of Office: MD9 2 Medical Drive #04-13 Singapore 117597

Location of Laboratory: MD9, #03-01

Name of Laboratory: Autophagy and Cancer Cell Biology


Research Areas of Interest:

  • Autophagy: Regulatory Mechanisms and Biological Functions in Cancer
  • Involvement of ROS and Oxidative Stress in Cell Death (Apoptotic and Non Apoptotic Cell Death)
  • Antioxidants and Natural Products as Anti-Cancer Agents

Selected Publications

  • Shi Y, Tan SH, Ng S, Zhou J, Yang ND, McMahon KA, del Pozo MA, Hill MA, Parton RG, Kim YS, Shen HM*. Caveolin-1 and lipid rafts play a critical role in determining cell stress responses in human breast cancer cells via modulation of autophagy and lysosomal function. Autophagy 11(5):769-84; 2015
  • Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM*. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Research. 2013 Apr;23(4):508-23. doi: 10.1038/cr.2013.11. Epub 2013 Jan 22.
  • Zhang J, Ng S, Wang J, Tan SH, Zhou J, Yang N, Lin Q, Xia D, Shen HM* Histone deacetylase inhibitors induce autophagy through FoxO1-dependent pathways Autophagy 11(4):629-42; 2015
  • Wu YT, Tan HL, Shi GH, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM*. Dual role of 3-methyladenine on modulation of autophagy via different temporal patterns on Class I and III PI3K. J Biol Chem 285:10850-10861,2010 This article was featured in Faulty of 1000 Biology
    (http://f1000biology.com/article/id/3091959/evaluation)
  • Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, Liu ZG, Ong CN, Shen HM*. Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 4:457-466, 2008. This article was accompanied by a Commentary from the Associate Editor published together in the same issue: White E. Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis. Autophagy

Awards

2015 Research Excellence Award, Yong Loo Lin School of Medicine, NUS
2011 Free Radical Biology and Medicine most cited paper 2006-2011 Award
2007 Research Excellence Award, Yong Loo Lin School of Medicine, NUS
2002 - 2003 Oncology Fellowship, National Cancer Institute (NCI), NIH, USA