The Department of Physiology Neurobiology Programme is broad-based and is home to attractive technical expertise and animal platform technology for pre-clinical investigations. The fundamental and pre-clinical research endeavors of the Programme span neurophysiology, neurochemistry and neuropharmacology and are focused on (a) calcium channels and their role in physiology and disease (Soong TW), (b) synaptic plasticity, learning and memory and cognition (Khanna, S; Lee CW; Soong TW; Sreedharan SK), (c) physiology and pathophysiology of motor systems (Soong TW), (d) neuroinflammation, stroke and neurodegenerative diseases (Ibanez C; Ling SC; Soong TW, Arumugam TV; Wong BS), (e) neurodevelopment (Ibanez C and Lee CW) and (f) neurobiology of acute and chronic pain (Khanna S). The animal models used for these investigations include transgenic mice model of ion channelopathies, Alzheimer’s and Parkinson’s disease, rat injury models of acute and chronic pain, models of stroke and rodent models of learning and memory. These models are complemented by a variety of techniques, ranging from in vitro patch clamp electrophysiology to in vivo electrophysiological recording from anaesthetized and behaving animal; and from molecular and cellular biology techniques to behavioral analyses.
The multifaceted work by the PIs is funded by several granting agencies, including NRF, NMRC, BMRC, and MOE. Moreover, to synergize with efforts made at the University level, the Principal Investigators (PIs) of the Programme are also members of the NUS Neurobiology/Ageing Programme based at the Life Sciences Institute, and they collaborate nationally and internationally with pre-clinical, clinical and/or engineering colleagues in order to strengthen the drive towards translation of pre-clinical findings to the bedside.