Department of Orthopaedic Surgery

Dr YANG Zheng, Ph.D.

 

Appointments:

  • Senior Research Fellow
    Department of Orthopaedic Surgery
    Yong Loo Lin School of Medicine
    National University of Singapore
  • Senior Research Fellow
    NUS Tissue Engineering Programme (NUSTEP)
    Life Sciences Institute
    National University of Singapore
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Contact

 

Qualifications

  • Ph.D. in Biochemistry, Monash University, Australia
  • B.Sc. (Honours Class I),  Monash University, Australia

 

Research Areas of Interests

  • Stem cell generated cartilage is currently suboptimal, lacking in terms of biochemical and mechanical quality, and does not acquire the zonal hierarchical arrangement of a physiological articular cartilage. My research focuses on cartilage tissue engineering using adult and embryonic stem cells, with the emphasis on the investigation of various microenvironmental cues on stem cell chondrogenic differentiation. Factors including the spatial-temporal delivery of bioactive agents, extracellular matrix biological component, topographical and mechanical cues of the scaffold are being studied with the aim of gaining knowledge for the future design of functional scaffold and pre-implantation culturing conditions for stem cell-based cartilage tissue engineering.  The interdisciplinary research involved collaboration with orthopaedic clinicians, chemical and mechanical engineers.

 

Selected Research Projects

  • Generation of phenotypically specific chondrogenic cells from human mesenchymal stem cells (MSCs)
  • Study of the effect of extracellular matrix (ECM) cues on MSC chondrogenesis
  • Study on the effect of matrix elasticity to the chondrogenic differentiation of stem cells
  • The use of elastomeric scaffold to study the effect of mechanical stimulation on cartilage tissue engineering

 

Selected Publications