Contact Our Departmental Secretary at: Tel: (+65) 6772 4342 Email: dossec@nus.edu.sg

James Goh Cho Hong

Primary Appointment:          Director of Research, Orthopaedic Surgery, NUHS Coordinator, Orthopaedic Diagnostic Centre, NUHS Secondary Appointment: Deputy Head (Admin & Comm), Division of Bioengineering, NUS Multidisciplinary Programmes: Interim Program Leader, Tissue Engineering Program, Life Sciences Institute, NUS Chair, Management Committee, NGS Graduate Program in Bioengineering, NUS Committees/Councils Member, Executive Committee, Graduate Program in Bioengineering, NGS, NUS Member, Institutional Animal Care and Use Committee, NUS Member, Management Advisory Committee, School of Mechanical and Manufacturing, Singapore Polytechnic Member, Medical Technology Standards Council, Spring Singapore Professional Societies President, Biomedical Engineering Society (Singapore) Chairman, Asia Pacific Working Group, International Federation of Medical and Biological Engineering Member, Administrative Council, International Federation of Medical and Biological Engineering Council Member, World Council of Biomechanics Secretary General, Asia-Pacific Association for Biomechanics Member, Executive Council, World Association for Chinese Biomedical Engineers Conferences Co-Chairman, Organising Committee, 12th International Conference on Biomedical Engineering, Dec 7 – 10, 2005, Singapore International Vice-President, World Congress on Medical Physics and Biomedical Engineering, August 27 – September 1, 2006, Seoul, Korea Chairman, Organising Committee, 3rd WACBE World Congress on Bioengineering, July 9 – 12, 2007, Bangkok, Thailand Chairman, Organising Committee, 13th International Conference on Biomedical Engineering, Dec 3 – 6, 2008, Singapore Member, International Advisory Board, 2nd World Congress on Tissue Engineering and Regenerative Medicine, Aug 31-Sept 3, 2009, Daejeon, Korea. Chairman, Organising Committee, 6th World Congress of Biomechanics, August 1 -6, 2010, Singapore Telephone: (65)6516 5259 Telefax: (65)6776 5322 Mail to: dosgohj@nus.edu.sg Mailing Address: James Goh, PhD Interim Program Leader NUS Tissue Engineering Program (NUSTEP) DSO (Kent Ridge) Building, 27 Medical Drive, Level 4 Singapore 117510
	For Prof. James's Research Interests Research Projects Selected Publications Selected Invited Papers at International Meetings Research Awards and Prizes
Qualifications
BSc (Hons) (1978), University of Strathclyde, Glasgow, UK, PhD (1982), University of Strathclyde, Glasgow, UK, CEng (1993), The Engineering Council, UK

Research Interests

1. Musculoskeletal Biomechanics
2. Functional Tissue Engineering
3. Orthopaedic Implants and Devices

Research Projects

1. Tissue Engineering approaches to the repair and regeneration of anterior cruciate ligament. BMRC grant (2003-2008) PI: JCH Goh; Co:PIs: SL Toh, EH Lee
2. Tissue Engineering In Musculoskeletal Tissue: Characterizing And Defining The Cellular And Molecular Mechanisms And At Their Role In Tissue Integration. BMRC grant (2003-2008) PI: EH Lee; Co:PIs: JHP Hui, B Lim, JCH Goh
3. A Study on Fusion Performance of the Novel Contoured Spinal Fixation Device in Conjunction with Stem Cells & Bone Morphogenetic Proteins in Lumbar Interbody Fusion. BMRC grant (2003-2008) PI: HK Wong; Co-PI: JCH Goh
4. Construction of a dynamic testing model for tibio-femoral joint. PI: JCH Goh; Co:PI: PVS Lee
5. RNAi for tendon healing: Synthetic small interfering RNA  decrease type V collagen synthesis for growing larger collagen fibrils. NMRC grant (2005-2008) PI: JCH Goh; Co:PI: R Lareu
6. Mechanical analysis of human lumbar facet joints after artificial disc replacement. BMRC grant (2003-2008) PI: HK Wong; Co-PI: JCH Goh
7. Mimicking Of Hard Tissue Formation And Implication To Human Health Care. ARF Tier 2 (2007-2010) PI: XY Liu; Co-PI: JCH Goh
8. Development of a fundamental tissue-engineered bone-ligament-bone graft with novel fixation device to bone tunnels for ACL reconstruction. BMRC grant (2008-2011)  PI: JCH Goh; Co:PIs: SL Toh, EH Lee, PH Too
9. ri-phasic silk/stem cell-based bone-ligament-bone construct in the repair of medial collateral ligament in rabbits. NMRC grant (2008-2010) PI: JCH Goh; Co:PIs: SL Toh, JHP Hui

Selected Publications

1. Ouyang, HW, JCH Goh, A Thambyah, SH Teoh and EH Lee, Use of knitted PLGA scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit Achilles tendon. Tissue Engineering, 9, 3 (2003): 431-439. (United States).
2. Shao XX, JCH Goh, DW. Hutmacher, EH Lee. Repair of large osteochondral defect using hybrid scaffolds seeded with bone marrow derived mesenchymal stem cells. Tissue Engineering  12(6) (2006):1539-51 (United States)
3. Thambyah A, A Nather, JCH Goh. Physical Characteristics of the Articular Cartilage beneath the Meniscus. Osteoarthritis and Cartilage, 14 (6) (2006):580-588  (United States)
4. Chong KS, Ang AD, Goh J, Hui J, Lim AYT, Lee EH, Lim BH. Bone marrow derived mesenchymal stem cells influence early tendon healing in a rabbit Achilles tendon model. Journal of Bone and Joint Surgery (Am) 2007;89:74-81
5. Ge Z, Fang F, Goh JCH, Ramakrishna S, Lee EH.  Biomaterials and scaffolds for ligament tissue engineering.  Journal of  Biomedical Materials Research A. 2006 Jun;77(3):639-52
6. Sahoo S, JCH Goh, SL Toh. Development of Hybrid Polymer Scaffolds for Potential Applications in Ligament and Tendon Tissue Engineering. Biomed. Mater. 2 (2007) 169-173 (United States)
7. Liu HF, HB Fan, SL Toh, JCH Goh. The interaction between a combined knitted silk scaffold and microporous silk sponge with human mesenchymal stem cells for ligament tissue engineering. Biomaterials 29 (2008) 662–674 (United Sates)
8. Fan HB, HF Liu, SL Toh, JCH Goh. Enhanced differentiation of mesenchymal stem cells co-cultured with ligament fibroblasts on gelatin/silk fibroin hybrid scaffold. Biomaterials 29 (2008): 1017–1027 (United Sates)
9. Liu HF, HB Fan, SL Toh, JCH Goh. A comparison of rabbit mesenchymal stem cells and anterior cruciate ligament fibroblasts responses on combined silk scaffolds. Biomaterials 29(2008): 1443-1453(United Sates)
10. eow CH, CH Cheong, KS Ng, PVS Lee, JCH Goh. Anterior cruciate ligament failure and cartilage damage during knee joint compression: a porcine study.  American Journal of Sports Medicine 2008; 36: 934-942 (United Sates)

Selected Invited Papers at International Meetings

1. Keynote Speaker: Goh JCH. Role of Biomechanics in Ligament and Tendon Tissue Engineering. 2nd Asia Pacific Conference on Biomechanics. November 2005, Taipei, Taiwan
2. Keynote Speaker: Goh JCH, PVS Lee, SL Toh. Role of Biomechanics in the Development of Lower Limb Prosthetics. World Congress on Medical Physics and Biomedical Engineering, August 27 to September 1, 2006, Seoul, Korea.
3. Keynote speaker: Goh JCH. Role of Biomechanics in Ligament Tissue Engineering. XXI Congress of International Society of Biomechanics, July 1 – 5, 2007, Taipei, Taiwan
4. Keynote speaker: Goh JCH, HF Liu, HB Fan, SL Toh. Potential application of silk-based scaffold in ligament tissue engineering. 3rd WACBE World Congress on Bioengineering, July 9 – 11, 2007, Bangkok, Thailand
5. Plenary speaker: Goh JCH. Challenges in Functional Ligament Tissue Engineering. International Conference on Advanced Technology in Experimental Mechanics 2007 & The Sixth Asian Conference on Experimental Mechanics, September 12-14, 2007, Fukuoka, Japan

Research Awards and Prizes

1. Albert Trillat Young Investigator's Award (2005), International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS)
   Title: Mechanical properties of articular cartilage covered by the meniscus."  Authors: A Thambyah, A Nather, JCH Goh
2. Outstanding Paper Award. 12th International Conference on Biomedical Engineering, Singapore, 7-10 Dec 2005.
   Title: ‘Optimization of polymer scaffolds for tendon and ligament tissue engineering.
   Authors: Sahoo S, JCH Goh, TE Tay, BKP Nayak, SL Toh.
3. Honorable Mention Award. The Asian Wall Street Journal’s Asian Innovation Awards. 27 Sep 2005.
   Title: Direct Pressure Cast Prosthetic Socket System. Inventor: Goh JCH, PVS Lee
4. Gold Medal Award (Postgraduate Category). Biomedical Engineering Society (Singapore) 4th Scientific Meeting 2007.
   Title: Mechanism of anterior cruciate ligament failure during impact compression of the knee joint’.  Authors: Yeow CH, KS Ng, C. Cheong, PVS Lee, JCH. Goh