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Research Projects
Current On-Going Research Projects
Assoc Prof Ho Khek Yu
mdchead@nus.edu.sg
- Intragastric Balloon for Treatment of Non-Alcoholic Steatohepatitis (NASH)
- Clinical Evaluation of Novel Biological Markers for the Prediction of Severe Acute Pancreatitis
- Central Processing and Intestinal Reaction to Visceral and Physical Stressors in Healthy Controls and IBS patients
- Development of robotic system to enhance therapeutic gastrointestinal (GI) endoscopic procedures
- Development of multi-functional ingestible microcapsule
- High resolution brain functional MR-imaging (fMRI) for the characterization of abnormal pain perception and response in functional bowel disease
- Exploring the efficacy and mechanism of action of a probiotic in irritable bowel syndrome
Assoc Prof Lim Seng Gee
mdclimsg@nus.edu.sg
- HBV Quasispecies Evolution during HBeAg Seroconversion and Antiviral Therapy
- To identify the Epitopes of HBeAg Seroconversion
- Analysis of splice variants of HBV
- Expression Profiling and Gene Silencing in Hepatocellular Carcinoma
- Establishment of an Animal Model for Chronic Hepatitis B Infection
- To characterise Host and Viral Factors between Patients with Clinical Liver Disease (abnormal LFTs, Cirrhosis and HCC) compared to those without Liver Disease (Hepatitis B carriers) in Chronic Hepatitis B patients
- To systematically evaluate the contributions of the Core Promoter and the Completed Genome in the Regulation and Fidelity of HBV Viral Replication
- A-STAR HBV Cohort Study with the main objective for characterizing the prognostic factors for different clinical phenotypes of Chronic Hepatitis B, together with immune and viral factors that lead to HBV-related events
- A-STAR HBV Immunovirology Programme
Assoc Prof Chen Chien-Shing
mdcccs@nus.edu.sg
- Development of an Early Phase Clinical Trials Oncology Program at the Cancer Institute (National Healthcare Group), in conjunction with the Cancer Therapeutics Research Group (CTRG)
- Development of the Transplantation Material Medical Research Centre at NUS/NUH: Therapeutic Applications in Haematological Malignancies and Solid Tumors
- Cancer Therapeutic Animal Model Program for Pre-Clinical Testing in NUS/NUH
- Singapore Cancer Society Terry Fox Cancer Research Grant 2004 - Preemptive CD8+ T-cell Depleted Donor Lymphocyte Infusion following Nonmyeloablative Stem Cell Transplantation (NMT) for Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome (MDS)
Asst Prof Dan Yock Young
- Cost Effectiveness Modeling of HBeAg seroconversion
- The Potential of Liver Progentor Cells
- Optimising Human hepatocytes from marginal livers for cellular therapeutics
Asst Prof Chen Lin Yee
- Identification of Novel Genetic Determinants of Atrial Fibrillation in an Asian Population
Assoc Prof Dale Fisher
mdcfda@nus.edu.sg
- Is the Inanimate Environment of Intensive Care Units an important reservoir facilitating the Development of Nosocomial Infection? A study facilitated by a Unit's Relocation at NUH, Singapore
- Outpatient Parenteral Antibiotic Therapy (OPAT) - Medical Capability Development Fund (MCDF)
- Costing MRSA and its control in a large hospital with highly prevalent disease
- Retrospective study of fatal cases of Dengue Haemorrhagic Fever and Dengue Shock Syndrome at NUH
Asst Prof Hsu Li Yang
- Identifying and categorizing the genes for carbapenem and inducible-cephalosporin resistance in local pathogenic Gram-negative bacili
Asst Prof Anselm Mak
- Cardiovascular risk, osteoporosis and psychosocial well-being: an association or a casual link?
- Serum levels of Protein S100B, anti N-Methyl-D-Aspartate receptor antibodies and functional magnetic resonance imaging in patients with neuropsychiatric systemic lupus erythematosus - a prospective study
Prof Oh Min Sen, Vernon
- Hypertension genes in Chinese adults with obesity and the metabolci syndrome (HYGENE-COMS)
Assoc Prof Paul Tambyah
- Community Acquired Methicillin-resistant S. aureus and penicillin non-susceptible S. pneumoniae carriage in healthy children attending day care centres
- BAXTER 810501: Phase I/II vaccine study of a novel whole cell vaccine against H5N1 influenza
Assoc Prof Ling Lieng Hsi
mdcllh@nus.edu.sg
- Multi-Slice Computed Tomography for detecting and quantitating Thoracic Aortic Atheromas: Comparison with transesophageal echocardiography and prediction of neurocognitive dysfunction after coronary artery bypass surgery
- Combination of Aortic Valve Calcium by multislice detector computed tomography and Serum pro-BNP levels as Prognostic Indicators of incremental value in patients with Aortic Stenosis
- Functional Assessment of Anthracycline Cardiomyopathy using NT pro-BNP and myocardial strain rate
- Functional assessment of severe organic mitral regurgitation using N-terminal pro-brain natriuretic peptide, myocardial strain rate imaging and heart rate variability
- Left ventricular dysfunction in a pacemaker population: Relation to pacing mode, mechanical dyssynchrony and N-terminal pro-B-type natriuretic peptide levels
Asst Prof Elaine Lim
mdclime@nus.edu.sg
- Differentiation of Human Embryonic Stem Cells (hESC) into Pneumocytes: Co-Culture of hESC with Foetal Lung Tissue
Asst Prof Adrian Low Fatt Hoe
mdclowa@nus.edu.sg
- Genetics of Acute Myocardial Infarction
- Evaluation of a novel international device
- Non-traditional cardiovascular risk factors
Assoc Prof Yeoh Khay Guan
mdcykg@nus.edu.sg
- "Identification of novel biomarkers for the screening of gastric cancer in Singapore" funded by Biomedical Research Council
- Establishment of a Gastric Cancer Epidemiology, Clinical and Genetics Programme (GCEP) Cohort Study of Patients at High Risk of Gastric Cancer (and Supplementary Study: Confocal GCEP)
- GASTRIC CANCER BIOMARKER DISCOVERY I (GASCAD I)
- GASTRIC CANCER BIOMARKER DISCOVERY II (GASCAD II)
- Pilot Study of the Use of Confocal Endomicroscopy in Resected Gastric Cancer Tissue (and Supplementary Study: Study of the Utility of Confocal Endoscopy in Gastric Cancer Patients)
- The Expression of RUNX3 and other molecular markers in human gastrointestinal tract and its malignancy
- Study of Colonoscopic Data over a 6-mth Period - Review of Colonoscopic Findings & Patient Demographics
- Asian Colorectal Adenoma Database: A six month collection of colonoscopis data
- Colorectal Adenoma Reminder Programme (CARP)
Dr Sim Khe Guan
mdcskg@nus.edu.sg
- The Functional Genomic Characterisation of TRIP-Br Integrator Function
- GCEP II: Extension to Establishment of a Gastric Cancer Epidemiology, Clinical and Genetics Programme (GCEP) Cohort Study of Patients at High Risk of Gastric Cancer
- Translational and Clinical Research Flagship Programme for The Singapore Gastric Cancer Consortium
Assoc Prof Thai Ah Chuan
mdctac@nus.edu.sg
- Characteristic Features of Asian Diabetics and Unique Differing Features
Assoc Prof Wilder-Smith Annelies
mdcwsa@nus.edu.sg
- Stimulated flight conditions and their impact on immunological markers
Assoc Prof Wilder-Smith Einar
mdcwse@nus.edu.sg
- Improved peripheral nerve diagnostics using neurophysiology and histopathology
- Skin immunocytochemical changes accompanying painful neuropathies
- Carpal tunnel syndrome diagnostics with clinical, neurophysiological and ultrasound methods
- Development of software for automatic detection of sleep, fluctuations of vigilance and emotion
- Diabetic neuropathy animal model for testing therapies
- Potential of autologous bone marrow treatment for diabetic peripheral neuropathy
- Earliest diagnosis and improved treatment strategies for leprosy
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