Research Focus & Grant

A. Research Focus

B. Research Grants

  • EBV DNA (TR–PCR) predictor of nasopharyngeal cancer. Early detection of Nasopharyngeal cancer with EBV-DUAL. (PI : A/Prof Luke Tan)
  • Clinical and immunologic effects of sublingual immunotherapy in patients with persistent allergic rhinitis: a double blind, placebo controlled study. (PI : A/Prog Wang De Yun)
  • Pathogenesis of nasal polyposis: role of leukotrines in recruitment and activation of CD8+ T cells. (PI : A/Prof Wang De Yun)
  • Tissue engineered prefabricated vascularised bone flaps. (PI : A/Prof Luke Tan)
  • Allergens for Diagnosis, Treatment and Control of Dust Mite Allergy (CO PI : A/Prof Wang De Yun)
  • The Role of fungus in allergic rhinitis. (PI : Dr Chao Siew Shuen)
  • Environmental control measures in persistent allergic rhinitis. (PI: Dr Chao Siew Shuen)
  • Genotypic and Phenotypic Correlations of Hereditary Non-Syndromic Hearing Loss in Singapore: Connexin 26, Connexin 30, Pendrin & A1555G Mutations. (PI : A/Prof Lynne Lim)
  • Efficacy of house dust mites avoidance measures in persistent allergic rhinitis. (CO PI : A/Prof Lynne Lim)
  • Establishing Normative Data For Central Auditory Procissing Disorder in school children. (CO PI : A/Prof Lynne Lim)
  • Role of Staphylococcus aureus superantigens (enterotoxin) in the pathogenesis of chronic rhinosinusitis and nasal polyposis. (PI : A/Prof Wang De Yun)
  • Impact of Stress on symptoms and underlying immunologic mechanism of allergic rhinitis. (PI : A/Prof Wang De Yun)
  • Computational modeling of geometrical configuration on human nose and its related physiologic functions in health and disease. (PI : A/Prof Wang De Yun)
  • Studies of self assembly between polymers and cyclodexterins and development of novel polyrotaxane – based DNA delivery system. (Co PI : A/Prof Wang De Yun)
  • Detecting early genetic changes in nasopharyngeal carcinoma using the screening model for first degree relatives of NPC patients. (PI : A/Prof Thomas Loh)
  • A systematic study of trismus in radiate nasopharyngeal carcinoma patients and the development of a clinical classification system for the severity and intervention of trismus. (PI : A/Prof Thomas Loh)
  • The detection of early nasopharyngeal carcinoma using a screening programme for siblings of affected patients. (PI : A/Prof Thomas Loh)
  • A Phase I Trial of 5-Azacitidine and Suberoylanilide hydroxiamic acid in patients with metastatic or locally recurrent Nasopharyngeal carcinoma and an nasal NK –T cell Lymphoma. (Co PI : A/Prof Thomas Loh)
  • The role of microbes in non–allergic rhinitis and otitis media with effusion in children. (PI : A/Prof Lynne Lim)
  • Screening of mitochondrial mutations in children with non–syndromic sensorineural hearing loss. With Children Medical Institute, National University Hospital. (Co PI : A/Prof Lynne Lim)
  • Efficacy of house dust mites avoidance in persistent allergic rhinitis. (PI : Dr Chao Siew Shuen)
  • A Genome Wide Association Study on Atopy and Allergic Diseases in Singpaore. (PI : A/Prof Wang De Yun)
  • Evaluation of the allergenicity of candida albicans and cladosporium herbarum by nasal challenge. (PI : Dr Chao Siew Shuen)
  • Targeting Epstein Barr Virus (EBV) associated malignancies using humanised HLA/LMP1 specific monoclonal antibodies. (PI : A/Prof Thomas Loh)
  • Apoptosis protease activating factor 1 (Apaf–1) mislocalization as a novel marker for drug resistance in nasopharyngeal carcinoma and head and neck squamous cell carcinoma. (PI : A/Prof Thomas Loh)
  • The design and use of Epstein Barr Virus–specific HLA tetramers to define the immunological basis underlying an association between certain HLA alleles and the risk of developing nasopharyngeal carcinoma. (PI : A/Prof Thomas Loh)
  • An evaluation of CD8+ T cell response to Epstein – Barr Virus in patients with Nasophayrngeal Carcinoma. (PI : A/Prof Thomas Loh)
  • A phase II radomised study of oral Selicilcib in patients with previously treated Nasopharyngeal Carcinoma. (PI : A/Prof Thomas Loh)
  • Development Of And Determination Of The Efficacy And Safety Of A Novel Drug–Eluting Absorbable Stent For Trachea Stenosis. (PI : A/Prof Lynne Lim)
  • Study of Nasonex (Mometasone Furoate Nasal Spray) for the Treatment of Nasal Polyps in Pediatric Subjects 6 to 18 years of Age. Double Blind Randomized Controlled Trial Multi–centre Multi-country multi centre study. (Co PI : A/Prof Lynne Lim)
  • Assessment of Nasal Patency via Multiphysics Simulations – from Physics to Medicine Subtitle: Phase II. Establishment of data human nose on normal and pathologic conditions. (PI : A/Prof Wang De Yun)
  • A genome–wide search for epigenetic alternations of genes important in development of nasal polyps. (PI : A/Prof Wang De Yun)
  • Management of Acute Rhinosinusitis in Primary Care Clinics in Asia-Pacific. (PI : A/Prof Wang De Yun)
  • A Genome–wide association study on atony and allergic diseases in Singaporean. (PI : A/Prof Wang De Yun)
  • Development Of And Determination Of The Efficacy And Safety Of A Novel Drug-Eluting Absorbable Stent For Trachea Stenosis. (Co PI : A/Prof Lynne Lim)
  • A Systematic Analysis of Trismus in Nasopharyngeal Carcinoma: A Clinically Practical Classification of Severity." (PI : A/Prof Thomas Loh)
  • Study to Unravel the Functional Biology of a Novel Interaction between the Anti-Apoptotic Protein, Bcl-2, and Mitochondrial Cytochrone C Oxidase Subunit VA in vitro and in Primary Cells Derived from Lymphome Patients. (Co PI : A/Prof Thomas Loh)
  • Development of a Noval Bioabsorbable drug-eluting ventilation tube for chronic middle east infection. (PI : A/Prof Lynne Lim)
  • Quantum dot–based microfluidic device for determining the etiology of rhinitis. (Co PI : Dr Loh Woei Shyang)
  • Prospectively Isolation of Cancer Stem Cell (CSCs) from Nasopharyngeal Cancer (NPC) tumor Biopsies (PI : Dr Yu Fenggang)
  • A Systematic study of Submucosal Nasopharyngeal Carcinoma: The Detection of Markers on Aggressive Tumour Behaviour for Treatment Targetting. (PI:A/Prof Thomas Loh)
  • Key Drivers of Tumor Growth in Nasal Polyposis (PI: A/Prof Wang De Yun)
  • Characterization of Atopy-Related IgE-Signalling Pathways by a Functional Genomics Approach (PI: A/Prof Wang De Yun)
  • Establishment of Primary Nasal Epithelial Stem / Progenitor Cells in an Air-liquid Interface Culture Model & Identification of Their Roles in infectious and allergic diseases of the upper airway (PI: A/Prof Wang De Yun)
  • Office-Based Ventilation Tube Applicator for Patients with Otitis Media with Effusion (A/Prof Lynne Lim)
  • An Automated Telephone-Adminstered Hearing Test for Mass Screening of Hearing Loss in Singapore (A/Prof Lynne Lim)
  • TLR-3 ligand as an immune adjuvant in cetuximab based therapy in Head and Neck Cancer (PI: Dr Lim Chwee Ming)
  • Comparing the use of I2R’s SleepMoniter II with conventional belts and ECG in the assessment of respiratory effort, heart rate and arrhythmia during polysomnography (PSG)." (PI: Dr Mark Thong)
  • Integrated analysis of somatic mutations and genomic aberrations in nasopharyngeal carcinoma (NPC) (PI:A/Prof Thomas Loh)
  • A Novel Biodegradable Ventilation Tube with Sustained Drug-Eluting Property for Treatment of Middle Ear Effusion (PI: A/Prof Lynne Lim)
  • Intensity of Cellular Infiltrates on Skin and Tumor Biopsies Correlates with Tumor Response and Skin Toxicity in Cetuximab based Therapy in Head and Neck Cancer (HNC) Patients (PI: A/Prof Lynne Lim)
  • Quantitative assessment of the virulence of rhinoviruses, influenza viruses and respiratory syncytial viruses and host defense mechanisms of human nasal epithelium in vitro (PI: A/Prof Wang De Yun)
  • A novel amplification device in speech impaired individuals (PI: A/Prof Thomas Loh)
  • BEP 2012-132 148 0014 Office-based ventilation tube applicator for patients with otitis media with effusion (PI: A/Prof Lynne Lim)
  • Objective Assessment of Facial Deformity for Surgical Applications (PI: Dr Loh Woei Shyang)
  • Mediated Entry and Stable Infection by Epstein-Barr Virus in NPC and normal nasopharyngeal epithelial cells. (PI: A/Prof Thomas Loh)
  • Real time in-vivo minature camera system in the long term surveillance of nasopharyngeal carcinoma (PI: Dr Lim Chwee Ming)
  • Gene and MiRNA expression analysis of cancer-associated fibroblasts in nasopharyngeal carcinoma (PI: Dr Joshua Tay Kai Xun)
  • Imaging of EBV associated tumors with a Radiolabeled Nucleoside (PI: A/Prof Thomas Loh)
  • Nasal Pharyngeal Cancer: Team Approach to Cure (PI: A/Prof Thomas Loh)
  • Reactivating autologous natural killer cells to target nasopharyngeal cancer (PI: Dr Lim Chwee Ming)
  • National Strategy for Hearing Health in Singapore (PI: Prof William Martin)
  • Restoring the apoptosis pathway enhances radiation-mediated cytotoxicity in nasopharyngeal cancer (PI: Dr Lim Chwee Ming)
  • Near-infrared auto-fluorescence Raman spectroscopy system in the surveillance of patients with nasopharyngeal cancer(PI: Dr Lim Chwee Ming)
  • Adaptive and Compliant Transoral Robotic Surgery with Flexible Manipulators and Intelligent Guidance (PI: Lim Chwee Ming)
  • Ex Vivo culture and molecular characterization of circulating NPS tumor cells potentially for individualized drug testing (PI: Dr Yu Fenggang)
  • The development of an orthotopic model of metastatic nasopharyngeal carcinoma using patient circulating tumor cells; implications for novel therapeutics (PI: A/Prof Thomas Loh & Dr Yu Fenggang)
  • A reproducible model for Influenza virus infection and coinfections of human nasal epithelial cells: towards transcriptomic signatures of susceptibility and severity (PI: Prof Wang Dr Yun)
  • Targeting Super-Enhancer Driven Transcripts in Nasopharyngeal Carcinoma through CDK7 inhibition (PI: A/Prof Thomas Loh)

C. Research Staff

Our dept currently have the following research staffs:

  • Senior Research Fellow: Dr Yu Fenggang, Dr Yan Yan
  • Specialist Associate: Serene Siow Chor Hiang, Judy Goh Han Lee
  • Research Associate: Gan Chee Wee, Isabel Leyritana
  • Research Assistant: Ong Hsiao Hui

D. Visiting Research Fellow

  • Dr Li Wen Xiou
  • Dr Feng Huijie / Shanghai Putuo District People's Hospital of China / 30 Jun 2008 – 19 Dec 2008
  • Dr Jin Yan / Dalin Municipal Central Hospital
  • Dr Yang Qintai / The Third Affiliated Hospital of Sun-Yat-Sen University Guang Zhou, China / 10 Dec 2012 – 09 June 2013
  • Dr Tang Qinglai / The Second Xiangya Hospital / 14 Apr 2014 – 13 Apr 2015
  • Dr Chen Zhuang-Gui / The Third Affiliated Hospital of Sun-Yat-Sen University Guang Zhou, China / 14 Apr 2014 – 14 Oct 2014
  • Dr Deng Yuqin / Renmin hospital of Wuhan University / 06 Aug 2015 – 05 Aug 2016
  • Dr Hong Haiyi / Fifth Hospital Affiliated with Sun Ya-sen University, Zhuhai, Guangdong Province, China / 21 Oct 2016 – 20 Oct 2017
  • Dr Tua Annika Luukkainen / Helsinki University / 17 May 2016 - 12 Apr 2017