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Cancer Biology |
We have active projects in cancer research, including telomerase function, cancer cell signaling, oxidative stress, micro RNAs
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Cell Signaling and
Gene Regulation |
Research subjects include Wnt signaling in C elegans; the STAT signaling pathway and its function; mechanisms of GDNF signals in neurons…
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Computational
Biology |
Computer protocols, applications and standards for biological entities, nomenclature, pathways, diagramming and software tools interfacing
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Epigenetics
Stem Cells and Development |
Dr. Ee Sin Chen reveals mechanisms of epigenetically control essential chromatin function; Dr Wu Qiang is aiming at understanding of epigenetic control of stem cells, A/P Caroline Lee and Theresa Tan studies microRNAs in cancer
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Free Radicals
Biology and Ageing |
Prof. Halliwell studies the molecular mechanisms of free radical (including nitric oxide) induced damage; A/P Clement works on superoxide dependent survival pathways in tumor cells…
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Fundamental Biochemistry |
Deciphering enzyme specificity and Mechanistic enzymology of enzymes of pharmaceutical importance; stable isotope techniques for studying element metabolism in humans with a special focus on iron and calcium…
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Infectious Diseases
and Host Defence |
Physiological functions of bacterial multidrug efflux pumps of Gram-negative bacteria (A/P Chua); Innate immunity against Burkholderia pseudomallei (A/P Gan & Tan TW), the immuno-pathological processes of Chikungunya virus (Dr. Lisa Ng)….
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Metabolism and
Lipid Research |
Application of lipid profiling ("lipidomics") as a novel and independent approach for the systems level scale analysis of biological systems…
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Molecular Cell
Biology |
We study functions of cell membrane dynamics and protein trafficking in mammalian cells, protein turn over etc...
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Neurosciences |
Molecular mechanisms of neurodegeneration; Nogos and the Nogo-66 receptor which are factors inhibiting CNS neuron regeneration GDNF signaling amd expression and functions in mouse central nervous system…
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Protein Sciences |
Oncoproteomics in cancer biomarker discovery; Structural study and mimetic design for protein-protein interactions critical for CNS neuronal development and regeneration. Enzyme evolution…
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