Research Staff


Genevieve

"Microglia are the resident macrophages of the central nervous system. I intend to investigate the role of the PI3K pathway in microglia in learning and memory and subsequently in diseases such as Alzheimer’s disease and to explore the possibilities of neuroprotection via this pathway.."

(PI: A/P Dheen ST)


Deepika

"I am studying how gestational diabetes alters the epigenetic, genetic, and molecular signature of fetus leading to the onset of neurological diseases.This will help us to derive novel biomarkers and therapeutic strategies, as well as to better understand the pathogenesis of neurological diseases."

(PI: A/P Dheen ST)


Aparna

"Microglia, the scavenger cells of the brain, are found in brain tumors and support the growth of the tumor. My project focuses on understanding molecular and epigenetic mechanisms that regulate microglial behaviour in tumors. This will lay the foundation for designing microglia-centric therapeutic strategies to treat brain tumors."

(PI: A/P Dheen ST)


Ramya

"Our lab focuses on identifying potential epigenetic marks that bring about robust change in gene expression leading to structural/or functional anomalies of the developing brain associated with diabetic pregnancy. My research interest is to investigate and validate various non-coding micro RNAs (miRNA) that are differentially expressed in neural stem cells from diabetic pregnancy. The expected outcome of our research is to narrow down on epidrugs to prevent brain anomalies that may follow diabetic pregnancy."

(PI: A/P Dheen ST)


Neelima

"Studying the Molecular and Epigenetic mechanisms underlying the Tumor-supportive phenotypes of Glioma-associated Microglia (GAMs) to understand the pathways which may switch the GAMs back to tumor suppressive phenotype for management of tumor progression."

(PI: A/P Dheen ST)


Ashwini

"My research work involves the study of the molecular and epigenetic mechanisms regulating tumor supportive behaviour of microglia in Glioma, a malignant brain tumor."

(PI: A/P Dheen ST)


Simbu

"Human Neuronal stem/Progenitors cells (hNSCs/hNPCs) are powerful research tool to address various neurodegenerative diseases (Alzheimer, dementia and microcephaly). My research interest is to understand and unleash the novel regulation of epigenetic changes (DNA methylation) as well as the role of non-coding RNAs (miRNAs and LncRNAs) during the neuropathological disease conditions."

(PI: A/P Dheen ST)


Shaun

"Diabetic wounds present with significant morbidity to patients, and the objective of our research is to examine the role of adipose-derived stem cells and silk scaffolds as agents for their treatment. Specifically, our aims are to investigate the extracellular matrix environment of adipose-derived stem cell interaction with nanofibrous biomaterial scaffold and to develop a tissue engineered animal model."

(PI: A/Prof Samuel Tay)


Suh Yee

"Parkinson's disease (PD) is an incapacitating neurodegenerative disorder that is prevalent in the aging population. Owing to many gaps in knowledge regarding this predominantly sporadic disease, current treatment methods only provide symptomatic relief and not neuroprotection. In our research, we hope to investigate the pathogenesis of PD from the miRNA perspective, in view of understanding the molecular mechanisms involved."

(PI: A/Prof Samuel Tay)


Jia Pei

"My research interest is in the field of cancer biology, particularly on the role of a transcription factor, Y-box binding protein-1 (YB-1) and its functional relevance in breast cancer metastasis."

(PI: Prof Bay BH)


Max Kosok

"Max Kosok is developing mass spectrometry based proteomics strategies to study cancer regulation for therapeutics. He is focusing on breast cancer with special interest in the triple negative subtype."

(PI: Prof Bay BH)


Cheng Teng

"Ng Cheng Teng's research interests focus on potential impacts of engineered nanomaterials on the environment and biological systems."

(PI: Prof Bay Boon Huat)


Valerie

“Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms comprising <1.0% of all breast tumours. Most PTs are benign; however, malignant PTs can behave aggressively by metastasizing to distant organs. The prognosis of patients with metastasis is dismal with high mortality rates. We aim to investigate the expression of biomarkers and their clinical significance in women with malignant PTs.”

(PI: Prof Bay Boon Huat)


Rita

"The interplay between hypoxic microenvironment, bone loss and inflammatory mediators in periprosthetic tissues from failed hip and knee joint replacements are being examined by histological and molecular techniques. Also the role of the inflammasome is being investigated."

(PI: Prof Charanjit Kaur)


Dhiraj

"Cellular and molecular mechanisms underlying periventricular white matter damage in the developing brain."

(PI: Prof Charanjit Kaur)


Xing Fei

"Investigation into the roles of glycosaminoglycans (GAG) and proteoglycans (PG) in breast, bladder and other cancer types. Transcriptomics and proteomics approaches are used to elucidate GAG-mediated signaling pathways that regulate tumor progression."

(PI: A/Prof George Yip)


Shiyuan

"My research focuses on understanding the pathological functions of chondroitin sulfate proteoglycans in breast cancer, which has the incidence and mortality rates among all cancers in females in Singapore. Specifically, my research aims to understand the roles played by chondroitin sulfate proteoglycans in breast cancer metastasis, and to identify the downstream proteins and signaling pathways"

(PI: A/Prof George Yip)

Wei Xuan

"Carbohydrates known as glycosaminoglycans (GAGs) were once thought as energy storage molecules. Recently however, they have been shown to affect cell properties and functions, thereby playing important roles in physiological and pathological conditions. Using a combination of molecular biology and immunohistochemistry, I aim to elucidate the pathological role of GAGs and their associated proteins known as proteoglycans in breast cancer."

(PI: A/Prof George Yip)

Hue San

"Glycosaminoglycans and proteoglycans have major roles in multiple cancer-related processes. My research interest is to study their downstream effectors and to determine if they can be utilised as cancer biomarkers and therapeutic targets."

(PI: A/Prof George Yip)

Ernest Addae

"Proteoglycans are of the extracellular matrix components of connective tissue. They are made up of glycosaminoglycan chains attached to a protein core. Our research focuses on evaluating proteoglycans in breast cancer, the commonest malignancy among women in Singapore and other parts of the world and most frequent cause of death. Discoveries made in my studies will be verified in breast cancer tissues."

(PI: A/ Prof George Yip)


Sharon

"My research interest involves how oxidative stress can affect stem cells maintenance using Drosophila melanogaster as a model organism."

(PI: Dr Baeg Gyeong Hun)


T.Doreen Portia

"My research interest relies on the development of a Drosophila melanogaster model as an unique platform to study nanoparticle-induced cyto- and genotoxicity."

(PI: Dr Baeg Gyeong Hun)


Charannya

"Role of non-coding RNAs (ncRNA) in various biological processes remain largely unexplored. My research interest is to examine the function of ncRNAs especially piRNAs in brain. This will give insights into identifying novel molecular circuits in brain and provide an innovative approach to develop RNA based therapeutics for people suffering from brain disorders"

(PI: Dr Hu Qidong)


Wang Cheng

"My research aims to elucidate the potential roles of splicing factors SRSFs and their kinases in acquired chemoresistance and the relevant alternative splicing events in breast cancers."

(PI: Dr Hu Qidong)


Junhong

"I work on cryopreservation of blood products in collaboration with DSO National Laboratories. My previous and current work involve a novel method of freezing human red blood cells, and optimization of a method to freeze human platelets, in conjunction with the optimization of blood components quality control assays. My next project is a clinical trial to assess the safety of frozen red blood cells."

(PI: E/Prof Ling Eng Ang)


Daryl

"My area of interest is in RNA higher order structures and editing of RNA by ADARs. Currently I am working to elucidate the editing complementary sequence of AZIN1, and any possible therapeutics that can work to stop the development of hepatocellular carcinoma."

(PI: Dr Polly Chen)