Academic Staff

Associate Professor
YIP Wai Cheong, George

(PhD; MBBS)

Deputy Director (Grant Administration), NUHS Research Office

 

Tel: +65 6516 3206
Email: georgeyip@nus.edu.sg
Office: MD10 #04-01S


Research Interests
  • Roles of glycosaminoglycans and proteoglycans in breast, prostate, gastric and other cancers
  • Wound healing
Current Projects
  • Determination of the functional roles of heparan and chondroitin sulfate proteoglycans in breast cancer, evaluation of their use as biomarkers and prognostic factors, and development of therapeutic targets
  • Vacancies are available for highly motivated and enthusiastic students who are keen to pursue their postgraduate studies in this area
Selected Publications
  • Iravani O, Bay BH, Yip GW (2017) Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1. Exp Cell Res 350:380-389. [PubMed]
  • Iravani O, Yip GW, Thike AA, Chua PJ, Scully OJ, Tan PH, Bay BH (2016) Prognostic significance of Claudin 12 in estrogen receptor-negative breast cancer. J Clin Pathol 69:878-883. [PubMed]
  • Poh ZW, Gan CH, Lee EJ, Guo S, Yip GW, Lam Y (2015) Divergent synthesis of chondroitin sulfate disaccharides and identification of sulfate motifs that inhibit triple negative breast cancer. Sci Rep 5:14355. [PubMed]
  • Scully OJ, Yu Y, Salim A, Thike AA, Yip GW, Baeg GH, Tan PH, Matsumoto K, Bay BH (2015) Complement component 1, q subcomponent binding protein is a marker for proliferation in breast cancer. Exp Biol Med (Maywood) 240:846-853. [PubMed]
  • Vijaya Kumar A, Salem Gassar E, Spillmann D, Stock C, Sen YP, Zhang T, van Kuppevelt TH, Hülsewig C, Koszlowski EO, Pavao MS, Ibrahim SA, Poeter M, Rescher U, Kiesel L, Koduru S, Yip GW, Götte M (2014) HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression. Int J Cancer 135:2579-2592. [PubMed]
  • Shin EM, Sin Hay H, Lee MH, Goh JN, Tan TZ, Sen YP, Lim SW, Yousef EM, Ong HT, Thike AA, Kong X, Wu Z, Mendoz E, Sun W, Salto-Tellez M, Lim CT, Lobie PE, Lim YP, Yap CT, Zeng Q, Sethi G, Lee MB, Tan P, Goh BC, Miller LD, Thiery JP, Zhu T, Gaboury L, Tan PH, Hui KM, Yip GW, Miyamoto S, Kumar AP, Tergaonkar V (2014) DEAD-box helicase DP103 defines metastatic potential of human breast cancers. J Clin Invest 124:3807-3824. [PubMed]
  • Lim GH, Tan PH, Jara-Lazaro AR, Thike AA, Sim WC, Yap VB, Yip GW (2014) Syndecan-1 is a potential biomarker for triple-positive breast carcinomas in Asian women with correlation to survival. Singapore Med J 55:468-472. [PubMed]
  • Guo T, Yu Y, Yip GW, Baeg GH, Thike AA, Lim TK, Tan PH, Matsumoto K, Bay BH (2014) Y-Box Binding Protein 1 is correlated with lymph node metastasis in intestinal type of gastric cancer. Histopathology 66:491-499. [PubMed]
  • Iravani O, Tay BW, Chua PJ, Yip GW, Bay BH (2013) Claudins and gastric carcinogenesis. Exp Biol Med (Maywood) 238:344-349. [PubMed]
  • Guo TT, Yu YN, Yip GW, Matsumoto K, Bay BH (2013) Silencing the YB-1 gene inhibits cell migration in gastric cancer in vitro. Anat Rec 296:891-898. [PubMed]
  • Wu YJ, Leong GS, Bao ZM, Yip GW (2013) Organisation of the neuroepithelial actin cytoskeleton is regulated by heparan sulfation during neurulation. Neurosci Lett 533:77-80. [PubMed]
  • Bahrom NA, Sirajudeen KNS, Yip GW, Latiff AA, Ghazali FC (2013) Sulfated glycosaminoglycans from crown-of-thorns Acanthaster planci - extraction and quantification analysis. Food Sci Nutr 1:83-89. [PubMed]
  • Scully OJ, Chua PJ, Harve KS, Bay BH, Yip GW (2012) Serglycin in health and diseases. Anat Rec 295:1415-1420. [PubMed]
  • Ibrahim SA, Yip GW, Stock C, Pan JW, Neubauer C, Poeter M, Pupjalis D, Koo CY, Kelsch R, Schüle R, Rescher U, Kiesel L, Götte M (2012) Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. Int J Cancer 131:E884-E896. [PubMed]
  • Scully OJ, Bay BH, Yip GW, Yu Y (2012) Breast cancer metastasis. Cancer Genomics Proteomics 9:311-320. [PubMed]
  • Lwin ZM, Yip GW, Chew FT, Bay BH (2012) Downregulation of ER60 protease inhibits cellular proliferation by inducing G1/S arrest in breast cancer cells in vitro. Anat Rec 295:410-416. [PubMed]
  • Masre SF, Yip GW, Sirajudeen KN, Ghazali FC (2011) Quantitative analysis of sulphated glycosaminoglycans content of Malaysian sea cucumber Stichopus hermanni and Stichopus vastus. Nat Prod Res 26:684-689. [PubMed]
  • Cao S, Bay BH, Yip GW (2011) Transcriptome profiling of murine spinal neurulation using laser capture microdissection and high-density oligonucleotide microarrays. Methods Mol Biol 755:375-384. [PubMed]
  • Teng YH, Tan WJ, Thike AA, Cheok PY, Tse GM, Wong NS, Yip GW, Bay BH, Tan PH (2011) Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy. Breast Cancer Res 13:R35. [PubMed]
  • Lai Y, Yip GW, Bay BH (2011) Targeting metallothionein for prognosis and treatment of breast cancer. Recent Pat Anticancer Drug Discov 6:178-185. [PubMed]
  • Yip GW (2011) Breast cancer: novel therapeutic targets. Recent Pat Anticancer Drug Discov 6:164-165. [PubMed]
  • Ng CT, Dheen ST, Yip GW, Ong CN, Bay BH, Lanry Yung LY (2011) The induction of epigenetic regulation of PROS1 gene in lung fibroblasts by gold nanoparticles and implications for potential lung injury. Biomaterials 32:7609-7615. [PubMed]
  • Soo ET, Ng CT, Yip GW, Koo CY, Nga ME, Tan PH, Bay BH (2011) Differential expression of metallothionein in gastrointestinal stromal tumors and gastric carcinomas. Anat Rec 294:267-272. [PubMed]
  • Lo SL, Thike AA, Tan SY, Lim TK, Tan IB, Choo SP, Tan PH, Bay BH, Yip GW (2011) Expression of heparan sulfate in gastric carcinoma and its correlation with clinicopathological features and patient survival. J Clin Pathol 64:153-158. [PubMed]
  • Zhan D, Zhao Y, Sun J, Ling EA, Yip GW (2010) High origin of radial arteries: a report of two rare cases. ScientificWorldJournal 10:1999-2002. [PubMed]
  • Lwin ZM, Guo C, Salim A, Yip GW, Chew FT, Nan J, Thike AA, Tan PH, Bay BH (2010) Clinicopathological significance of calreticulin in breast invasive ductal carcinoma. Mod Pathol 23:1559-1566. [PubMed]
  • Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S,
    Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW (2010) miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. Oncogene 29:6569-6580. [PubMed]
  • Toh PP, Li JJ, Yip GW, Lo SL, Guo CH, Phan TT, Bay BH (2010)Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro. Exp Dermatol 19:987-993. [PubMed]
  • Lai Y, Lim D, Tan PH, Leung TK, Yip GW, Bay BH (2010) Silencing the metallothionein-2A gene induces entosis in adherent MCF-7 breast cancer cells. Anat Rec 293:1685-1691. [PubMed]
  • Yu YN, Yip GW, Tan PH, Thike AA, Matsumoto K, Tsujimoto M, Bay BH (2010) Y-box binding protein 1 is up-regulated in proliferative breast cancer and its inhibition deregulates the cell cycle. Int J Oncol 37:483-492. [PubMed]
  • Chua PJ, Lee EH, Yu YN, Yip GW, Tan PH, Bay BH (2010) Silencing the peroxiredoxin III gene inhibits cell proliferation in breast cancer. Int J Oncol 36:359-364. [PubMed]
  • Nikolova V, Koo CY, Ibrahim SA, Wang Z, Spillmann D, Dreier R, Kelsch R, Fischgräbe J, Smollich M, Rossi LH, Sibrowski W, Wülfing P, Kiesel L, Yip GW, Götte M (2009) Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Carcinogenesis 30:397-407. [PubMed]
  • Yap X, Tan HY, Huang J, Lai Y, Yip GW, Tan PH, Bay BH (2009) Over-expression of metallothionein predicts chemoresistance in breast cancer. J Pathology 217:563-570. [PubMed]
  • Tay WL, Yip GW, Tan PH, Matsumoto K, Yeo R, Ng TP, Kumar SD, Tsujimoto M, Bay BH (2009) Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer. Mod Pathol 22:282-290. [PubMed]
  • Lim D, Jocelyn KM, Yip GW, Bay BH (2009) Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells. Cancer Lett 276:109-117. [PubMed]
  • Chua PJ, Yip GW, Bay BH (2009) Cell cycle arrest induced by hydrogen peroxide is associated with modulation of oxidative stress related genes in breast cancer cells. Exp Biol Med (Maywood) 249:1086-1094. [PubMed]
  • Kaur C, Sivakumar V, Yip GW, Ling EA (2009) Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflammation in the hypoxic developing brain. Glia 57:336-349. [PubMed]
  • Teng YH, Ang HS, Mao KZ, Lui JY, Lin JY, Yue LL, Loh HL, Chiang G, Yip GW, Tan PH (2009) Glomerular basement membrane thickness in an Asian population using a novel image analysis software. Pathology 41:342-347. [PubMed]
  • Shoba B, Lwin ZM, Ling LS, Bay BH, Yip GW, Kumar SD (2009) Function of sirtuins in biological tissues. Anat Rec (Hoboken) 292:536-543. [PubMed]
  • Teng YH, Tan PH, Chia SJ, Zam NA, Lau WK, Cheng CW, Bay BH, Yip GW (2008) Increased expression of non-sulfated chondroitin correlates with adverse clinicopathological parameters in prostate cancer. Mod Pathol 21:893-901. [PubMed]
  • Koo CY, Sen YP, Bay BH, Yip GW (2008) Targeting heparan sulfate proteoglycans in breast cancer treatment. Recent Pat Anticancer Drug Discov 3:151-158. [PubMed]
  • Chen MH, Yip GW, Tse GM, Moriya T, Lui PC, Zin ML, Bay BH, Tan PH (2008) Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters. Mod Pathol 21:1183-1191. [PubMed]
  • Selvarajan S, Sii LH, Lee A, Yip GW, Bay BH, Tan MH, Teh BT, Tan PH (2008) Parafibromin expression in breast cancer: a novel marker for prognostication? J Clin Pathol 61:64-67. [PubMed]
  • Götte M, Spillmann D, Yip GW, Versteeg E, Echtermeyer FG, van Kuppevelt TH, Kiesel L (2008) Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome. Hum Mol Genet 17:996-1009. [PubMed]
  • Yip GW, Rajendran K (2008) SnapAnatomy, a computer-based interactive tool for independent learning of human anatomy. J Vis Commun Med 31:46-50. [PubMed]
  • Soo ET, Ng YK, Bay BH, Yip GW (2008) Heat shock proteins and neurodegenerative disorders. ScientificWorldJournal 8:270-274. [PubMed]
  • Soo ET, Yip GW, Lwin ZM, Kumar SD, Bay BH (2008) Heat shock proteins as novel therapeutic targets in cancer. In Vivo 22:311-315. [PubMed]
  • Guo CH, Koo CY, Bay BH, Tan PH, Yip GW (2007) Comparison of the effects of differentially sulphated bovine kidney- and porcine intestine-derived heparan sulphate on breast carcinoma cellular behaviour. Int J Oncol 31:1415-1423. [PubMed]
  • Thimmegowda NR, Nanjunda Swamy S, Ananda Kumar CS, Sunil Kumar YC, Chandrappa S, Yip GW, Rangappa KS (2007) Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Bioorg Med Chem Lett 18:432-435. [PubMed]
  • Lange K, Kammerer M, Hegi ME, Grotegut S, Dittmann A, Huang W, Fluri E, Yip GW, Götte M, Ruiz C, Orend G (2007) Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization. Cancer Res 67:6163-6173. [PubMed]
  • Smollich M, Götte M, Yip GW, Yong ES, Kersting C, Fischgrabe J, Radke I, Kiesel L, Wulfing P (2007) On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer. Breast Cancer Res Treat 106:361-369. [PubMed]
  • Ananda Kumar CS, Nanjunda Swamy S, Thimmegowda NR, Benaka Prasad SB, Yip GW, Rangappa KS (2007) Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Med Chem Res 16:179-187. Read more...
  • Tan LH, Tan PH, Tan SY, Ventura R, Yip GW, Zhou YC, Do E, Koay ES, Kwan C, Poh BK, Peh S (2007) Inflammatory myofibroblastic tumour of the bladder may express anaplastic lymphoma kinase by translocation-dependent and translocation-independent mechanisms: a report of two cases. Histopathology 50:278-82. [PubMed]
  • Du HY, Li Y, Olivo M, Yip GW, Bay BH (2006) Differential up-regulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin. Oncol Rep 16:1397-402. [PubMed]
  • Götte M, Yip GW (2006) Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective. Cancer Res 66:10233-7. [PubMed]
  • Lim CN, Ho BC, Bay BH, Yip GW, Tan PH (2006) Nuclear morphometry in columnar cell lesions of the breast: is it useful? J Clin Pathol 59:1283-6. [PubMed]
  • Yip GW, Smollich M, Götte M (2006) Therapeutic value of glycosaminoglycans in cancer. Mol Cancer Ther 5:2139-48. [PubMed]
  • Koo CY, Bay BH, Lui PC, Tse GM, Tan PH, Yip GW (2006) Immunohistochemical expression of heparan sulfate correlates with stromal cell proliferation in breast phyllodes tumors. Mod Pathol 19:1344-50. [PubMed]
  • Seidler DG, Faiyaz-Ul-Hague M, Hansen U, Yip GW, Zaidi SH, Teebi AS, Kiesel L, Götte M (2006) Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (β4GalT-7). J Mol Med 84:583-94. [PubMed]
  • Lim D, Phan TT, Yip GW, Bay BH (2006) Up-regulation of metallothionein isoforms in keloid keratinocytes. Int J Mol Med 17:385-9. [PubMed]
  • Tan PH, Jayabaskar T, Yip GW, Tan Y, Hilmy M, Selvarajan S, Bay BH (2005) p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. Mod Pathol 18:1527-34. [PubMed]
  • Du HY, Olivo M, Chen YJ, Yip GW, Tan PH, Matsumoto K, Tsujimoto M, Bay BH (2005) Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo. Int J Mol Med 16:865-8. [PubMed]
  • Tan PH, Aw MY, Yip GW, Bay BH, Sii LH, Murugaya S, Tse GM (2005) Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? Am J Surg Pathol 29:625-32. [PubMed]
  • Tan PH, Bay BH, Yip GW, Selvarajan S, Tan P, Wu J, Lee CH, Li KB (2005) Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death. Mod Pathol 18:374-81. [PubMed]
  • Zou XH, Foong WC, Cao T, Bay BH, Ouyang HW, Yip GW (2004) Chondroitin sulfate in palatal wound healing. J Dent Res 83:880-5. [PubMed]
  • Yip GW, Ferretti P, Copp AJ (2002) Heparan sulphate proteoglycans and spinal neurulation in the mouse embryo. Development 129:2109-19. [PubMed]
Honours & Awards
  • Clinician Scientist Award, National Medical Research Council, Singapore, 2012
  • Best Research Presentation Award, 14th World Congress on Advances in Oncology and 12th International Symposium on Molecular Medicine, 2009
  • National University of Singapore Annual Teaching Excellence Award, 2007/2008
  • Yong Loo Lin School of Medicine Faculty Teaching Excellence Award, 2007/2008
  • Japan Society for the Promotion of Science (JSPS) Fellowships, 2005 and 2011
  • Scholarship, Kazato Research Foundation and 8APEM, 2004
  • International Fellowship, A*STAR, 2002-2003
  • Travel Scholarships, Microscopy Society (Singapore), 2002, 2004 and 2006
  • Best Biological Sciences Poster Prize, 3rd ASEAN Microscopy Conference and 19th Annual Conference of the Electron Microscopy Society of Thailand, 2002
Other Appointments
  • Assistant Dean of Research (Grants), Yong Loo Lin School of Medicine, National University of Singapore
  • President, Microscopy Society (Singapore)
  • Editorial Board Member, TheScientificWorldJournal
  • Editorial Board Member, World Journal of Clinical Oncology
  • Editorial Board Member, BioScience Trends
  • Editorial Board Member, The Open Pathology Journal
  • Editorial Board Member, Glycobiology Insights
  • Editorial Board Member, Bone and Tissue Regeneration Insights
  • Editorial Board Member, Journal of Medical & Biological Sciences
  • Editorial Board Member, Annals of Microscopy
  • Coordinator, Graduate Research Seminar Module (MDG5771)
  • Coordinator, Honours Project in Life Sciences (LSM4199)
  • Coordinator, Undergraduate Research Opportunities Programme in Science (UROPS)
  • Deputy Director (Grant Administration), NUHS Research Office