Academic Staff

Professor
ONG Wei Yi

(PhD; BDS)

Director, Electron Microscopy Unit, Yong Loo Lin School of Medicine, NUS

Tel: +65 6516 3662
Email: wei_yi_ong@nuhs.edu.sg

Centre for Life Sciences
National University of Singapore
28 Medical Drive, #04-09, Singapore 117456


Research Interests
  • Translational Aspects of Lipid Biology in the Central Nervous System
  • Health Effects of Engineered Nanomaterials
Selected Publications

 

  • Chong JR, Xiang P, Wang W, Hind T, Chew WS, Ong WY, Lai MKP, Herr DR. Sphingolipidomics analysis of large clinical cohorts. Part 2: Potential impact and applications. Biochem Biophys Res Commun. 2018 Apr 11. pii: S0006-291X(18)30844-1. doi: 10.1016/j.bbrc.2018.04.075. [Epub ahead of print] PubMed PMID: 29654757.
  • Herr DR, Ong JH, Ong WY. Potential Therapeutic Applications for Inhibitors of Autotaxin, a Bioactive Lipid-Producing Lysophospholipase D, in Disorders Affecting the Nervous System. ACS Chem Neurosci. 2018 Mar 21;9(3):398-400.
  • Ong WY, Wu YJ, Farooqui T, Farooqui AA. Qi Fu Yin-a Ming Dynasty Prescription for the Treatment of Dementia. Mol Neurobiol. 2018 Feb 7. doi: 10.1007/s12035-018-0908-0. [Epub ahead of print] Review. PubMed PMID: 29417476.
  • Liu C, Zhang CW, Zhou Y, Wong WQ, Lee LC, Ong WY, Yoon SO, Hong W, Fu XY, Soong TW, Koo EH, Stanton LW, Lim KL, Xiao ZC, Dawe GS. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2017 Dec 13. doi: 10.1038/s41418-017-0005-3.
  • Ho CF, Bon CP, Ng YK, Herr DR, Wu JS, Lin TN, Ong WY. Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochem Res. 2017 Dec 12. doi: 10.1007/s11064-017-2448-9.
  • Goh WJ, Zou S, Ong WY, Torta F, Alexandra AF, Schiffelers RM, Storm G, Wang JW, Czarny B, Pastorin G. Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative. Sci Rep. 2017 Oct 30;7(1):14322. doi: 10.1038/s41598-017-14725-x.
  • Tan LH, Tan AJ, Ng YY, Chua JJ, Chew WS, Muralidharan S, Torta F, Dutta B, Sze SK, Herr DR, Ong WY. Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. Mol Neurobiol. 2017 Oct 17. doi: 10.1007/s12035-017-0784-z.
  • Wu JS, Kao MH, Tsai HD, Cheung WM, Chen JJ, Ong WY, Sun GY, Lin TN. Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPβ-Driven PPAR-γ Transcription. Mol Neurobiol. 2017 Sep 23. doi: 10.1007/s12035-017-0776-z.
  • Li ZY, Chung YH, Shin EJ, Dang DK, Jeong JH, Ko SK, Nah SY, Baik TG, Jhoo JH, Ong WY, Nabeshima T, Kim HC. YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2. J Neuroinflammation. 2017 Apr 27;14(1):94. doi:10.1186/s12974-017-0866-x.
  • Shalini SM, Ho CF, Ng YK, Tong JX, Ong ES, Herr DR, Dawe GS, Ong WY. Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory. Mol Neurobiol. 2017 Feb 8. doi: 10.1007/s12035-017-0413-x.
  • Loke SY, Wong PT, Ong WY. Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension. Neurochem Int. 2017 Jan;102:33-56. doi: 10.1016/j.neuint.2016.11.010. Epub 2016 Nov 25.
  • Chew WS, Shalini SM, Torta F, Wenk MR, Stohler C, Yeo JF, Herr DR, Ong WY. Role of prefrontal cortical calcium-independent phospholipase A(2) in antinociceptive effect of the norepinephrine reuptake inhibitor antidepressant maprotiline. Neuroscience. 2017 Jan 6;340:91-100. doi: 10.1016/j.neuroscience.2016.10.037.
  • Shalini SM, Herr DR, Ong WY. The Analgesic and Anxiolytic Effect of Souvenaid, a Novel Nutraceutical, Is Mediated by Alox15 Activity in the Prefrontal Cortex. Mol Neurobiol. 2017 Oct;54(8):6032-6045. doi: 10.1007/s12035-016-0138-2.
  • Chen Y, Bang S, McMullen MF, Kazi H, Talbot K, Ho MX, Carlson G, Arnold SE, Ong WY, Kim SF. Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia. Mol Neurobiol. 2017 Apr;54(3):1699-1709. doi: 10.1007/s12035-016-9773-x.