Academic Staff

Professor
ONG Wei Yi

(PhD; BDS)

Assistant Head (Anatomy), Director EM Unit YLLSOM

 

Tel: +65 6516 3662
Email: antongwy@nus.edu.sg
Office: MD10 #04-01L


Research Interests
  • Translational Aspects of Lipid Biology in the Central Nervous System
  • Health Effects of Engineered Nanomaterials
Selected Publications
  • Loke SY, Wong PT, Ong WY. Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension. Neurochem Int. 2016 Nov 24. pii: S0197-0186(16)30472-7. doi: 10.1016/j.neuint.2016.11.010.
  • Too IH, Yeo H, Sessions OM, Yan B, Libau EA, Howe JL, Lim ZQ, Suku-Maran S, Ong WY, Chua KB, Wong BS, Chow VT, Alonso S. Enterovirus 71 infection of motor neuron-like NSC-34 cells undergoes a non-lytic exit pathway. Sci Rep. 2016 Nov 16;6:36983. doi: 10.1038/srep36983. PubMed PMID: 27849036.
  • Chew WS, Shalini SM, Torta F, Wenk MR, Stohler C, Yeo JF, Herr DR, Ong WY. Role of prefrontal cortical calcium-independent phospholipase A(2) in antinociceptive effect of the norepinephrine reuptake inhibitor antidepressant maprotiline. Neuroscience. 2016 Oct 24;340:91-100. doi: 10.1016/j.neuroscience. 2016.10.037.
  • Shalini SM, Herr DR, Ong WY. The Analgesic and Anxiolytic Effect of Souvenaid, a Novel Nutraceutical, Is Mediated by Alox15 Activity in the Prefrontal Cortex. Mol Neurobiol. 2016 Oct 1. [Epub ahead of print] PubMed PMID: 27696115.
  • Ong WY, Sun GY, Wood WG, Lin TN. Nutraceuticals in Neurodegeneration and Aging. Neuromolecular Med. 2016 Sep;18(3):239-40. doi: 10.1007/s12017-016-8432-8. PubMed PMID: 27507593.
  • Tan CS, Ho CF, Heng SS, Wu JS, Tan BK, Ng YK, Sun GY, Lin TN, Ong WY. Clinacanthus nutans Extracts Modulate Epigenetic Link to Cytosolic Phospholipase A2 Expression in SH-SY5Y Cells and Primary Cortical Neurons. Neuromolecular Med. 2016 Sep;18(3):441-52. doi: 10.1007/s12017-016-8404-z. PubMed PMID: 27319010.
  • Tsai HD, Wu JS, Kao MH, Chen JJ, Sun GY, Ong WY, Lin TN. Clinacanthus nutans Protects Cortical Neurons Against Hypoxia-Induced Toxicity by Downregulating HDAC1/6. Neuromolecular Med. 2016 Sep;18(3):274-82. doi: 10.1007/s12017-016-8401-2. PubMed PMID: 27165113.
  • Chen Y, Bang S, McMullen MF, Kazi H, Talbot K, Ho MX, Carlson G, Arnold SE, Ong WY, Kim SF. Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia. Mol Neurobiol. 2016 Feb 12. [Epub ahead of print] PubMed PMID: 26873854; PubMed Central PMCID: PMC4982840.
  • Tan CS, Ng YK, Ong WY. Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. Mol Neurobiol. 2016 Aug;53(6):3854-72. doi: 10.1007/s12035-015-9314-z. PubMed PMID: 26162318.
  • Chew WS, Ong WY. Regulation of Calcium-Independent Phospholipase A2 Expression by Adrenoceptors and Sterol Regulatory Element Binding Protein-Potential Crosstalk Between Sterol and Glycerophospholipid Mediators. Mol Neurobiol. 2016 Jan;53(1):500-17. doi: 10.1007/s12035-014-9026-9. PubMed PMID: 25482049.
  • Tan JW, Ho CF, Ng YK, Ong WY. Docosahexaenoic acid and L-Carnitine prevent ATP loss in SH-SY5Y neuroblastoma cells after exposure to silver nanoparticles. Environ Toxicol. 2016 Feb;31(2):224-32. doi:10.1002/tox.22037. PubMed PMID: 25146533.
Other Appointments
  • Assistant Head, Department of Anatomy, Yong Loo Lin School of Medicine, NUS
  • Director, Electron Microscopy Unit, Yong Loo Lin School of Medicine, NUS