Academic Staff

Senior Lecturer
Harve Subramhanya KARTHIK




Tel: +65 6516 7391
Office: MD10 #04-01H

Research Interests
  • Medical Education
    Under this sector, the main emphasis is on developing novel methods of anatomy teaching by means of models that demonstrate fundamental and key concepts of human anatomy and models that are functionally competent to show how the various anatomical structures work.
  • Human Cadaveric Anatomy
    In this regard, the main research focus is on dissecting and investigating variations in the structural anatomy of human organ systems which have implications in clinical and surgical anatomy.
Current Projects
  • A study on the application of model-based teaching in enhancing the learning of anatomy by medical students has been just completed.
    Grant: CDTL funded Teaching Enhancement Grant on the project entitled: “Enhancing the learning of anatomy for the doctors of tomorrow: Strong foundations, safe hands”. Period: 2010-2011
  • NUHS Leadership in Academic medicine Mentorship (NLAM) award to develop novel methods in student assessment.
  • Academic Medicine Development Award (AMDA) by NUHS for FY2012.
Selected Publications
  • Harve KS, Lareu R, Rajagopalan R, Raghunath M. Understanding how the crowded interior of cells stabilizes DNA/DNA and DNA/RNA hybrids-in silico predictions and in vitro evidence. Nucleic Acids Research. 2010 Jan;38(1):172-81.
  • Harve KS, Vigneshwar R, Rajagopalan R, Raghunath M. Macromolecular Crowding as means of emulating cellular interiors in vitro: when less might be more. PNAS, 2008 Dec 23;105(51)
  • Lareu RR, Harve KS, Raghunath M. Emulating a crowded intracellular environment in vitro dramatically improves RT-PCR performance. BBRC. 2007. 363(1):171-7.
  • Lareu RR, Subramhanya KH, Peng Y, Benny P, Chen C, Wang Z, Rajagopalan R, Raghunath, M. Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: the biological relevance of the excluded volume effect. FEBS Lett. 2007 Jun 12;581(14):2709-14. Epub 2007 May 21.
  • Lareu RR, Arsianti I, Subramhanya HK, Yanxian P, Raghunath M. In vitro enhancement of collagen matrix formation and crosslinking for applications in tissue engineering: a preliminary study. Tissue Eng. 2007 Feb;13(2):385-91.
  • Shukkur EA, Shimohata A, Akagi T, Yu W, Yamaguchi M, Murayama M, Chui D, Takeuchi T, Amano K, Subramhanya KH, Hashikawa T, Sago H, Epstein CJ, Takashima A, Yamakawa K. Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. Hum Mol Genet. 2006 Sep 15;15(18):2752-62. Epub 2006 Aug 4.
  • H.S. Karthik, R. R. Lareu, R. Rajagopalan and M. Raghunath. Macromolecular crowding in biological systems: Dynamic Light Scattering (DLS) to quantify the Excluded Volume Effect. Biophys. Rev. Lett, Vol. 1, No. 3 (2006) 317-325
  • Oxalate mediated nephronal impairment and its inhibition by c-phycocyanin: A study on urolithic rats. Shukkur Muhammed Farooq, Abdul Shukkur Ebrahim, Karthik Harve Subramhanya, Ramasamy Sakthivel, Nachiappa Ganesh Rajesh, Palaninathan Varalakshmi. Mol. cell Biochem. 2006; 284(1-2):95-101. Epub 2006 Feb 14.
Other Appointments
  • Reviewer, Singapore Medical Journal since 2010
Professional Organizations
  • Singapore Neuroscience Association