Academic Staff

Assistant Professor
HU Qidong

(PhD, BSc)

 

Tel: +656601 3730
Email: anthq@nus.edu.sg
Office: MD10 #04-01U


Research Interests
  • Role of non-coding RNAs in nuclear receptor signalling  programs
  • Relationship between chromatin reorganization and gene regulation in steroid hormone-dependent cancers
  • Novel functions of the Notch signalling pathway and their implication in demyelinating diseases
Current Projects
  • Investigate the DNA repeat-derived non-coding RNAs in retinoic acid receptor-regulated neuronal development. The recent study has identified a new class of small RNAs, riRNAs, which downregulate stem cell signatures transcripts, leading to the proliferation arrest.  Based on preliminary observations, we further hypothesize that riRNAs actively participate in neuronal differentiation.
  • Cross-talk between riRNAs and microRNAs. Pilot experiments have provided exciting evidence that the two types of small RNAs cross-talk with each other in maintaining stem cell pluripotency and directing cell fate selection. Furthermore, they share and compete for some common RNA processing machinery, yet exhibiting distinctive regulatory activities at both the transcriptional and post-transcriptional levels.
Selected Publications
  • Liu ZJ*, Hu QD*, Rosenfeld MG. Complexity of the RAR‐Mediated Transcriptional Regulatory Programs. Retinoic Acid Signaling (Volume 1, Chapter 10) (2014) In Press. (* co-first authors)
  • Hu QD, Rosenfeld MG. Epigenetic Regulation of Human Embryonic Stem Cells.  Front Genet (2012) Nov 5; 3: 238. (Cited 4 times by Google Scholar)
  • Hu QD, Tanasa B, Trabucchi M, Li WB, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation.          Nat Struct Mol Biol (2012) Nov; 19(11):1168-75. (Cited 7 times by Google Scholar)
  • Zhou ZH, Qiu JS, Liu W, Zhou Y, Plocinik RM, Li HR, Hu QD, Ghosh G, Adams JA, Rosenfeld MG, Fu XD. The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus.   Mol Cell (2012, cover story) 47(3):422-33. (Cited 30 times by Google Scholar)
  • Hu QD,* Kwon YS,* Nunez E,* Cardamone MD, Hutt KR, Ohgi KA, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG, Fu XD. Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules.    Proc Natl Acad Sci USA (2008) 105(49):19199-204. (*co-first authors) (Cited 181 times by Google Scholar)
  • Hu QD, Ma QH, Gennarini G, Xiao ZC. Cross-talk between F3/Contactin and Notch at axoglial interface: a role in oligodendro-cyte development.    Dev Neurosci (2006) 28(1-2):25-33. (Cited 27 times by Google Scholar)
  • Nie DY, Ma QH, Law JW, Chia CP, Dhingra NK, Shimoda Y, Yang WL, Gong N, Chen QW, Xu G, Hu QD, Chow PK, Ng YK, Ling EA, Watanabe K, Xu TL, Habib AA, Schachner M, Xiao ZC. Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp.    Neuron Glia Biol (2006) 2:151-164. (Cited 28 times by Google Scholar)
  • Cui XY,* Hu QD,* Tekaya M, Shimoda Y, Ang BT, Nie DY, Sun L, Hu WP, Karsak M, Duka T, Takeda Y, Ou LY, Dawe GS, Yu FG, Ahmed S, Jin LH, Schachner M, Watanabe K, Arsenijevic Y, Xiao ZC. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.    J Biol Chem (2004) 279, 25858-25865. (*co-first authors) (Cited 85 times by Google Scholar)
  • Hu QD, Cui XY, Ng YK, Xiao ZC. Axoglial interaction via the notch receptor in oligodendrocyte differentiation. Ann Acad Med Singapore (2004) 33(5): 581-588. (Cited 9 times by Google Scholar)
  • Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC. F3/Contactin acts as a functional ligand for Notch during oligodendrocyte maturation.                      Cell (2003) 115, 163-175. (Cover story) (Cited 231 times by Google Scholar)
  • Ang BT, Hu QD, Xiao ZC. The paranode in the CNS: functional molecular complex of axo-glial interaction. Progress in Neuroscience (2002) pp268-274 (Higher Education Press, China)
  • Tang JJ, Chen X, Hu QD, Kato M, Shimizu K, Yokoo M. A comparatively histological observation on the megagametophytic abortion of female-sterile rice FS-1 and its maternal parent Fujisaka 5. Acta Biologiae Experimentalis Sinica (2002) 35, 313-318. (Cited 4 times by Google Scholar)
Honours & Awards
  • Sigma-Xi Full Membership:2010.6- present    
  • Postdoctoral Fellowship: 2007.4—2010.3;  Cancer Research Institute, USA
  • Chua Toh Hua Memorial Gold Medal: 2006.6;   National University of Singapore
  • Postgraduate Scholarship: 2001.7—2005.2;    National University of Singapore
Other Appointments
  • Assistant Project Scientist: 2011.4--2013.12; University of California, San Diego
  • Postdoctoral Fellow: 2007.4--2011.3; University of California, San Diego
  • Research Associate: 2006.8--2007.3;  Howard Hughes Medical Institute at UCSD