Academic Staff

Instructor
Dhanarajan Rajakumar

(PhD; MSc; BSc)

 

Tel: +65 6516 5495
Email: antdr@nus.edu.sg
Office: MD10 #04-01M


Research Interests
  • Role of proteoglycans in breast cancer.
  • Free radicals in the Pathophysiology of cancer.
Selected Publications
  • Combinatorial mutagenesis of the voltage-sensing domain enables the optical resolution of action potentials firing at 60 Hz by a genetically-encoded fluorescent sensor of membrane potential. Hong Hua Pioa, Dhanarajan Rajakumar, Bok Eum Kang, Eun Ha Kim, and Baker. J. Neurosci., January 7, 2015.35(1):372–385. 
  • Involvement of oxidative stress, Nuclear Factor kappa B and the Ubiquitin proteasomal  pathway in dysferlinopathy" Dhanarajan R, Senthilnathan S, Mathew Alexander and Anna Oommen. Life Sceicnes. June 2014. 
  • Oxidative stress, NF-κB and the ubiquitin proteasomal pathway in the pathology of calpainopathy, R Dhanarajan, M Alexander and A Oommen. Neurochem Res. 2013 Jul 12.  
  • Degradation of myofibrillar proteins and inadequate antioxidants in selective muscle wasting of Limb girdle muscular dystrophy,  R Dhanarajan, AB Patil, M Alexander, G Chacko and A Oommen. International Journal of case report and Images. 2011,2(6),6-11. 
  • Protective effect of Ebselen, a selenoorganic drug, against gentamicin induced renal damage in rats, Dhanarajan R, Abraham P and Isaac B.  Basic & Clinical Pharmacology & Toxicology. 2006, 99, 267-272.
  • V220 mutants of genetically encoded voltage sensors based on Ci-VSP. Dhanarajan Rajakumar and Bradley J Baker (Manuscript in preparation).
International Conference Publications
  • Nitric oxide signaling in selective muscle wasting of Miyoshi myopathy. Dhanarajan R, Alexander M and Oommen A. Neuromuscular Disorders. 2009,19, 585.
  • Pathomechanisms of neuromuscular disorders: oxidative stress, NF-kB and intracellular calcium link the absence of a transmembrane protein to muscle cell death. R. Dhanarajan, J Sivaguru, S.Senthildathan, M Alexander and A Oommen.  J Neurochemistry. 2010, 113 (Suppl. I) 6.  
  • Curcumin to treat the neuromuscular disorder dysferlinopathy. R Dhanarajan, M Alexander and A Oommen. J Neurochemistry. 2011, 118 (Suppl.I).152. 
  • V220 Mutants of Ciona Voltage-Sensing Domain Based Genetically Encoded Fluorescent Voltage Sensors. D Rajakumar, H Piao, BE Kang, A Jung, EH Kim, BJ Baker Biophysical Journal 108 (2), 151a-152a.  
Honours & Awards
  • Awarded Travel grant to present work at the 23rd Biennial meeting of ISN ESN, August 2011, Athens, Greece.
  • Awarded partial support to attend the "Redox Biology course for PhD students, March, 2011 at Montevideo, Uruguay.
  • Awarded the best poster award in the International conference on recent advancements and therapeutics in free radical research and 10th Annual meeting of the Society of Free radical Research, India, held in January, 2011, Chennai, India.
  • Awarded fellowship to attend The 13th Summer School of Myology, 2010, Paris, France.
  • Awarded Wood-Whelan Research Fellowship from “International Union of Biochemistry and Molecular Biology” (IUBMB), 2010.
  • Awarded Young Scientist Fellowship to present work at The 4th ISN special Neurochemistry Conference on “Membrane domains in CNS physiology and pathology” 2010, Sicily, Italy.
  • Awarded travel grant to attend “The ISN International school on Lipidomics in the nervous system cell” 2010, Acitrezza, Italy.
  • Awarded travel grant to participate in The International workshop on Microscopy, 2010, at National Centre for Biological Sciences, Bangalore, India.
  • Awarded World Muscle Society travel fellowship to present poster at The 14th World Muscle Congress, 2009, Geneva, Switzerland.
Other Appointments
  • 2013 – 2015: Postdoctoral Fellowship, Center for Functional Connectomics, World Class Institute, Korea Institute of Science and Technology (KIST), Seoul, South Korea.
Professional Organizations
  • International Brain Research Organization (IBRO).
  • Treat-NMD Neuromuscular network (TREAT-NMD).
  • Treat-NMD Alliance
  • International Society for Free Radical Research (ISFRR).
  • Reviewer: Neuropathology and Applied Neurobiology