Academic Staff

Assistant Professor
BAEG Gyeong Hun

(PhD, MSc, BSc)

Tel: +65 6516 7973
Office: MD10 #04-01T

Research Interests
  • Identification and characterization of the somatic mutant alleles of Jak3 in cancer patients
  • Identification and characterization of the small molecules that inhibit JAK3 activation
  • Role of the JAK/STAT signaling pathway in stem cell maintenance and self-renewal
Current Projects
  • Role of the JAK/STAT pathway in the Drosophila male germ-line stem cell self-renewal
    The JAK/STAT pathway is one of the critical regulators of stem cell maintenance and self-renewal in mammals and in Drosophila.However, the target genes that act downstream of JAK/STAT signaling in either mammals or Drosophila to promote self-renewal are as-yet unknown. This lack of knowledge is a significant impediment to the development of novel therapeutics in regenerative medicine and cancer treatment. The objectives of this study are to identify the downstream target genes of JAK/STAT signaling and to determine the cellular function of those genes in the Drosophila male germ-line stem cell self-renewal.
Areas of Collaborative Research
  • Development of animal models of hematopoietic malignancies based on JAK kinase activation
Selected Publications
  • Kim B.-H., Kim M,, Yin C.H., Jee J.-G., Sandoval C., Lee H., Bach E.A., Hahm D.-H. and Baeg G.-H. (2011). Inhibition of JAK3 activity alleviates inflammation in monoarthritic rats. British Journal of Pharmacology 164:106-18.
  • Kim B.-H., Min Y.-S., Choi J.-S., Baeg G.-H., Kim Y., Shin J.-W., Kim T.-Y. and Ye S.-K. (2011). Benzoxathiol Derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Exp. Mol. Med. 43(5):312-321.
  • Yin C.H., Bach E.A. and Baeg G.-H. (2011). Development of a high-throughput cell-based reporter assay for screening of JAK3 inhibitors. Journal of Biomolecular Screening 16(4): 443-449.
  • Kim B.-K., Jee J.-G., Yin C.H., Sandoval C., Kitamura D., Bach E.A. and Baeg G.-H. (2010). NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Molecular Cancer 9:36.
  • Kim B.-H., Oh S.R., Yin C.H., Lee S., Kim E.A., Kim M.S., Sandoval C., Jayabose S., Bach E.A., Lee H.K. and Baeg G.-H. (2010). MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. British Journal of Haematology 148:132-43.
  • Kim B.K., Yin, C.H., Guo Q., Bach E.A., Lee H., Sandoval C., Jayabose S., Ulaczyk-Lesanko A., Hall D. and Baeg G.-H. (2008). A small molecule compound identified through a cell-based screening  inhibits JAK/STAT pathway signaling in Human cancer cells. Molecular Cancer Therapeutics 7:2672-80.
  • Bach A., Ekas L.A., Ayala A., Flaherty M.S., Perrimon N. and Baeg G.-H. (2007). GFP reporters detect the activation of The Drosophila JAK/STAT pathway in vivo. Gene Expression Pattern 7; 323-331.
  • Ayala-Camargo A., Ekas L.A., Flaherty M.S., Baeg G.-H. and Bach EA. (2007). The JAK/STAT pathway regulates  Proximo-distal patterning in Drosophila. Developmental Dynamics 236; 2721-2730.
  • Ekas A. L., Baeg G.-H., Flaherty M.S., Ayala A. and Bach E.A. (2006). JAK/STAT signaling Promotes regional specification by negatively regulating wingless expression in Drosophila. Development 133; 4721-4729.
  • Baeg G.-H., Zhou R. and Perrimon N. (2005). Identification of novel JAK/STAT signaling components by a cell-based genome-wide RNA interference screen in Drosophila. Genes & Development 19; 1860-1870.
  • Baeg G.-H., Selva E. M., Goodman R. M., Dasgupta R. and Perrimon N. (2004). The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycans receptors. Developmental Biology 276; 89-100. (Cover Article)
  • Liu C., Li Y., Semenov M., Han C., Baeg G.-H., Tan Y., Zhang Z., Lin X.  and He X. (2002). Control of b-Catenin  Phosphorylation Degradation by a Dual-Kinase Mechanism. Cell 108; 1-20.
  • Selva E., Hong K., Baeg G.-H., Beverley S. M., Turco S. J., Perrimon N. and Hacker U. (2001). Dual role of the fringe  connection gene in both heparan sulfate and fringe-dependent signaling events. Nature Cell Biol. 3(9); 809-815.
  • Baeg G.-H., Lin X., Khare N., Baumgartner S. and Perrimon N. (2001). Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development 128; 87-94.
  • Baeg G.-H. and Perrimon N. (2000). Functional binding of secreted molecules to heparan sulfate proteoglycans in  Drosophila. Curr. Opin. Cell Biol. 12; 575-580.
  • Adachi J., Kohno T., Baeg G.-H., Akiyama T. and Yokota J. (1997). Growth suppression of non-small cell lung carcinoma cells by the introduction of the p16INK4A gene. Int. J. Oncol. 10; 33-39.
  • Higuchi O., Baeg G.-H., Akiyama T. and Mizuno K. (1996). Suppression of fibroblast cell growth by overexpression of LIM-kinase 1. FEBS Letters 396; 81-86.
  • Senda T., Miyashiro I., Matsumine A., Baeg G.-H., Monden T., Kobayashi S., Monden M., Toyoshima M. and Akiyama  T. (1996). The tumor suppressor protein APC colocalizes with b-catenin in the colon epithelial cells. Biochem.  Biophys.  Res.  Commun.  223; 329-334.
  • Matsumine A., Senda T., Baeg G.-H., Roy B. C., Nakamura Y., Noda M., Toyoshima K. and Akiyama T. (1996). MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. J. Biol. Chem. 271; 10341-10346.
  • Matsumine A., Ogai T., Senda N., Okumura K., Satoh T., Baeg G.-H., Kawahara T., Kobayashi S., Okada M., Toyoshima K. and Akiyama T. (1996). Binding of APC to the human homolog of the Drosophila Disc Large Tumor Suppressor Protein.  Science 272; 1020-1023.
  • Baeg G.-H., Matsumine A., Kuroda T., Bhattacharjee R. N., Miyashiro I., Toyoshima K. and Akiyama T. (1995). The  tumor suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO  J. 14; 5618-5625.
  • Miyashiro I., Senda T., Matsumine A., Baeg G.-H., Kuroda T., Shimano T., Miura S., Noda T,. Kobayashi S., Monden M., Toyoshima K. and Akiyama T. (1995). Subcellular localization of the APC protein: Immunoelectron microscopic  study of the association of the APC protein with catenin. Oncogene 11; 89-96.
  • Baeg G.-H., Sakurai Y. and Shimazaki K. (1993). Maturation processes in female Loligo Bleekeri Keferstein (Mollusca: Cephalopoda). The Veliger 36; 228-235.
  • Baeg G.-H., Sakurai Y. and Shimazaki K. (1992). Embryonic stages of Loligo Bleekeri Keferstein (Mollusca:  Cephalopoda). The Veliger 35; 234-241.
Honours & Awards
  • Postdoctoral Fellowship Award, The Medical Foundation/Charles A King Trust, USA
  • Graduate Student Fellowship Award, Ministry of Education, Japan
Other Appointments
  • 1999 – 2005: Postdoctoral Fellow, Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA, USA
  • 2006 – 2011: Assistant Professor, Department of Pediatrics, New York Medical College, Valhalla, NY, USA
Professional Organizations
  • Member - Children’s Oncology Group (USA)