The research emphasis of the laboratory is on translational clinical research which is geared towards patient care.

Major research themes of the laboratory are:

  • Isolation of novel neuropeptides involving in pain
  • Identifying the mechanism of neuropeptides for analgesic development
  • Pain and sensory research using animal models
  • Biomarkers for pain assessments

 

Principal Investigators

A/Prof Ti Lian Kah
anatilk@nus.edu.sg

  • Cardiac Anaesthesia
  • Cardiopulmonary Bypass
  • Medical Education and Simulation

Prof Lee Tat Leang
analeetl@nus.edu.sg

  • Novel neuropeptides involved in pain
  • Equipment for airway management

A/Prof Low Chiang Ming
chian_ming_low@nuhs.edu.sg

  • Neuropharmacololgy
  • Pain and neuroinflammation
  • Precision medicine

 

Research Team Members

Dr Tan Chee Kuan Francis (Senior Research Fellow)

Project involves the isolation of the interacting protein partners of a novel neuropeptide, designated p56, which has been isolated from the cerebrospinal fluid of chronic pain patients. The p56 peptide itself and its N-terminal end are found to be nociceptive whereas the C-terminal end is analgesic. Isolating its protein/receptor interacting partner will allow the understanding of the mechanism of action of p56, thereby allowing us to use it as a starting point for developing a new generation of analgesics.

 

Dr Li Chunmei (Sr Laboratory Executive)

Have more than 10 years of experience in research lab. Assisted research projects and gained proficiency in a range of laboratory techniques e.g. High Performance Liquid Chromatography (HPLC), cell culture, enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA) and animal work.

 

Ms Liu Weiling (Research Assistant / M.Sc Candidate)

Research interest is in the mechanistic pathway of chronic pain. Currently, I am investigating the pathophysiological mechanism of paclitaxel, a chemotherapeutic drug, in neuropathic pain using animal model. Concurrently, I am also discovering possible biomarkers and identifying the underlying mechanisms behind chronic osteoarthritic pain by studying the cerebrospinal fluid of chronic osteoarthritis patients.